Low-dose Naltrexone for Hashimoto’s Thyroiditis. A Game Changer.

Low-dose Naltrexone for Hashimoto's. A Game Changer.

Low-dose Naltrexone. Have you heard of it?

Written by Tristin Halie Fleetwood


When I was 14 I began to have severe migraines and chronic stomach issues. What I didn’t know was I would spend the next 10 years of my life seeking out over 20 medical professionals, receive 13 different diagnoses and over 30 pharmaceutical prescriptions.

In 2016 I was tested for the 4th time to see if I had the thyroid autoimmune disease called Hashimoto’s thyroiditis. It seemed to be the only answer my naturopath could come up with to explain my thyroid tribulations. I dreaded those test results. I thought my life was for sure going to be over if that diagnosis came back positive.

I walked into my follow up appointment and laying on the desk in bold print with my name on the top of the document was the word I’d feared for so many years. Just sitting there, mocking me was the word HASHIMOTO’S. To say that I was angry would be a severe understatement. I felt betrayed by every other health care professional I’d ever seen. Why had it taken this long to find this seemingly simple answer?

I argued with that piece of paper. I argued with the blood results. I argued with my body asking it countless questions about why it hadn’t given me the signs sooner (even though it had). Mid sob session, I looked up at my doctor and said I want to fight this. I’ve heard of ways to rid the antibodies from the body and I’m going to do exactly that. I refused to be defined by that diagnosis. I was going to have children someday. I’d battled my thyroid symptoms for so many years already and in that moment I decided the only way to move forward from this was to take matters into my own hands.

Low-dose Naltrexone for Hashimoto's. A Game Changer.

Have you heard of LDN?

LDN, short for Low-dose Naltrexone, is a wondrous medication that helps treat many autoimmune conditions. It can reduce the thyroid antibodies of Hashimoto’s thyroiditis. Yes. It happened to me.

Naltrexone originally developed in the early 1960s is used in much higher doses to address the symptoms and withdrawals in chronic drug users. It helps block the effects of opioids and reduces drug cravings.

Low-dose Naltrexone & The Immune System

Dr. Bernard Bihari is credited with the discovery of the benefits of Low-dose Naltrexone for normalizing immune system function in his groundbreaking clinical trial of LDN on patients with HIV/AIDS at Downstate Medical Center in 1985-86.[1]

It is termed Low-dose Naltrexone because the amount of naltrexone used is in micro doses compared to the amount given for drug addiction. Studies have now found that Low-dose Naltrexone can be used to effectively treat autoimmune diseases including Inflammatory Bowel Disease, Multiple Sclerosis, Crohn’s Disease, and fibromyalgia.[2-7]

There were very few known risks to taking this prescription, so I found an LDN physician and dove right in.

A local compounding pharmacy created a batch of capsules for me to start my first month’s journey on this medication. The pharmacist provided me with as much education as she could and expressed to me how excited she was for me to try this process. She informed me that I would be experiencing some vivid dreams for the next several weeks, but otherwise that was the only side-effect anyone had reported back to her. She then asked me to keep a journal of my thyroid symptoms and how they were progressing as I went through my treatment. This particular pharmacist had been following the medical journals on Low-dose Naltrexone for many months and was very intrigued to work with someone directly on this matter.

The pharmacist was 100% correct on the vivid and sometimes peculiar dreams. I experienced those for almost 3 weeks, but continued to achieve restful and deep sleep each evening, despite the extreme curiosity for my subconscious’s dream selection. I continued taking the recommended doses for 1 month, then dropped down to the lower dose recommended by my physician. I took the prescription for just shy of 6 months before seeking out another blood test to find out if my levels had shifted.

The results of my next blood test completely blew my mind. In less than 6 months, my thyroid antibodies had become clinically insignificant. For those of you who don’t know what that means…it means they were GONE! That’s right, you read that correctly.

The antibodies that were once attacking my thyroid were no longer significant enough to show up in a blood test. Did that mean I was completely rid of my Hashimotos? Unfortunately, no. Now that my body had developed the antibodies, it was something that could always stir back up later down the line. However, in this moment I was western medicine’s version of Hashimoto’s FREE. The number of emotions that overcame me were so vast I couldn’t hardly stand. I felt liberated, powerful, relieved, and so amazed at how my body was actually healing. I had lost faith in the power of my body so long ago as I battled one illness after the next.

THERE IS MORE…Hashimoto’s & Infections

Now that I had my Hashimoto’s temporarily under control, my next task was to discover the underlying causes of my digestion issues. In July 2017 I went to the Mayo Clinic in Rochester, MN where they found that I had an active staph-infection which had likely been plaguing my body for over 10 years. The infection had caused issues with my thyroid, digestion, adrenal glands, sleep patterns, white blood cell count, and more. Once they isolated the infection and began treatment, I was quickly able to function like a normal (I’ve never been all that normal, it makes life a little more fun) 24 year old.

Digestion Issues? It could be your Pelvic Floor!

Another piece to my Mayo Clinic journey was nothing short of shocking to me was my diagnosis of Pelvic Floor Dyssynergia. This condition doesn’t allow the pelvic floor muscles to relax properly, particularly during a bowel movement. Here is a quote from the International Foundation for Functional Gastrointestinal Disorders.

The pelvic floor is composed of a group of muscles that span the underlying surface of the bony pelvis, which function to allow voluntary urination and defecation. “Paradoxical contraction” refers to an abnormal increase of pelvic floor muscle activity with defecation, rather than the normal decrease in muscle activity that is necessary in order to have a normal bowel movement. This condition can contribute to some forms of constipation, complaints of incomplete evacuation, and straining with stool. Because pelvic floor muscles are controlled voluntarily, their function can be improved through various learning procedures – such as biofeedback.

With a few semi-invasive yet simple tests, the gastroenterologists were able to diagnose this disorder in less than a day. After having a half a dozen other doctors diagnose me with IBS (irritable bowel syndrome) time and time again, this new discovery made so much more sense. While in Rochester, I took part in 2 brief sessions of bio-feedback training, which is essentially Physical Therapy of the pelvic floor monitored with electronic devices. After these sessions, I was able to understand so much more about how my body was processing food and trying to dispose of the waste material, simply by learning which muscles were functioning improperly. Upon returning back to my home in Bozeman, MT, I was participating in pelvic floor physical therapy on an at home basis 3-5 times a day. My digestion and bowel movements drastically improved and are still improving to this day. Where I used to have ZERO relief with my constipation and diarrhea, I now have an understanding of my body and am able to work with it instead of against it.

Even after all this healing, I still experience migraines, but on a much less frequent basis. I manage my compromised immune system and thyroid through a combination of Chinese Medicine and lifestyle care including coaching, counseling, proper diet, acupuncture, massage, exercise, meditation, chiropractic and LOTS of self-care.

LDN for Hashimoto's

Much Love,

Tristin Halie Fleetwood

Genuine Vitality [dot] com


  1. Bernard Bihari, MD: Low-dose Naltrexone for Normalizing Immune System Function. Alternative Therapies. 2013 March/April. 19(2):56-65.
  2. Khong, K.P., et al. Alteration of prescription-only drug utilization by low dose naltrexone users with hypothyroidism. A cohort study based on the Norwegian prescription database from 2011-2015. Research in Social & Administrative Pharmacy. 2017 May-June. 13(3):e9.
  3. Raknes, G., et al. The effect of Low Dose Naltrexone on Medication in Inflammatory Bowel Diseases: A Quasi Experimental before-and-after Prescription Database Sudy. J Crohns Colitis. 2018 Jan 27. doi: 10.1093/ecco-jcc/jjy008.
  4. Frech, T., et al. Low-dose naltrexone for pruritus in systemic sclerosis. Int J Rheumatol. 2011;2011:804296.
  5. Brown, N., Panksepp, J. Low-dose naltrexone for disease prevention and quality of life. Med Hypotheses. 2009 Mar;72(3):333-7.
  6. Tawfik, D.I., et al. Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn’s disease in rats. Neuropeptides. 2016 Oct;59:39-45.
  7. Parkitny, L., Younger, J. Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia. Biomedicines. 2017 Apr 18;5(2).pii:E16.

READ NEXT: The Secret Poison that Drives Hashimoto’s

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About Dana Trentini

Dana Trentini founded Hypothyroid Mom October 2012 in memory of the unborn baby she lost to hypothyroidism. This is for informational purposes only and should not be considered a substitute for consulting your physician regarding medical advice pertaining to your health. Hypothyroid Mom includes affiliate links including the Amazon Services LLC Associates Program.


  1. I have inflammation of thyroid very painful does LDN help

  2. I have Hashimoto’s for two years, I am also in perimenopause, so dealing with the symptoms ugh! My TPO was 535 when I was diagnosed 2 years ago Now with supplements and lifestyle changes is 135. I just started LDN for 3 days , and the headaches are so irritating. After reading all these positive post I will probably go back yo LDN. Wish me luck.😁

  3. Glenda Montgomery says

    I have been to Barnes hospital in st louis and mayo in Rochester. No one could figure it out. Alot of raised eyebrows and accused of anorexia. (I weighed 94 lbs) i cant gain any weight and have always been that way my entire life. I am so hungry but I can’t eat. If I do I feel like I have taken a bottle of Nyquil or Benadryl. I am nonresponsive. My GYN took bloodwork and sent me an email and gave me LDN 10mg. Haven’t started it yet. I hate medicine and its side effects. Thanks for the ccx article. Guess I’ll try it.

  4. Hi Tristin,
    such a promising article!
    Izabella Wentz (thyroidpharmacist.com) talks about LDN.
    During threatment with LDN did you follow the special diet (AIP f.ex)? Are you following the diet after you ABs came back to norm? How about your thyroid panel blood test? Do you take some meds? Some supplements?
    How about your gut (bacteria, Viruses) health? The reason why we have Hoshimoto is our gut issues. Adrenals can be restored easily, but it is very difficult to restore the gut health (especially when you was born with some issues (mother had gut issues, no breastfeeding etc)
    Thank you.

  5. Thanks for sharing your journey!

    I have a different story – hoping someone might be able to relate. So far, no doctors have been able to explain why this happened.

    I’m 37. Have always been healthy with what people would consider a “fast metabolism”. Thin, active, and could easily gain muscle.

    I became addicted to opiates for 10 years.

    Upon getting sober, I was placed on naltrexone 50mg as an “opiate blocker” and to help with cravings. The naltrexone treatment was stopped 6 months into sobriety. That month, my hair started falling out. My muscles hurt. I began gaining weight, even after attempting to correct my diet. Started losing even MORE hair. I’ve lost about 50% of my hair in 4-5 months.

    A doctor finally checked my thyroid levels – they were within normal limits but my antibodies were through the roof. I was diagnosed with Hashimoto and placed in a low dose Nature-thyroid.

    I asked to be placed back on the naltrexone I was on before my hair started falling out. I started it 2 days ago.

    I’m curious if the opioid abuse and then the naltrexone was just holding off Hashimoto from developing all those years. Anyone have any idea?

    Thanks !

  6. Can I ask how they diagnosed the staph infection? I am keen to get this assessed with me? how did they treat it? Thank you so much for this, I was wondering if I continue with my naltrexone that I have not long started, decided to keep going!

  7. Ilaria Poggesi says

    Dear Tristin,
    Thank you for sharing this amazing content!
    I have Hashimoto’s disease but my problem is that I have huge quantities of auto antibodies so I am on HRT and I take huge quantities of thyroidal hormones.
    My question is: is there a protocol for patients who are on hrt but want to test ldn?
    I am looking for it, but cannot find it.
    Could you help?
    I would like to know the dosage of ldn and if it works how do I reduce the hrt?
    Thank you so much for any help.
    Love from Italy.

  8. You are doing amazing work! Thanks for sharing your wonderful posts. I was at my worst when I discovered LDN. Low dose Naltrexone helps me a lot. I’m on 4.5 mg. Made me feel better, helped with skin conditions. I get 50mg naltrexone pills (a way cheaper from “GETLDN247” ❤️, just Google it), than get it compounded into 4.5mg doses. I’ve been doing this a few years with volumetric dosing. 50ml of distilled water with a 50mg tab of Naltrexone. Dose 4.5mg (4.5ml) with an oral syringe.

  9. Did you by any chance keep a journal of your recovering using LDN? I was wondering how long it took to start feeling somewhat normal again.

  10. Thank you so much for sharing. I begin the LDN Monday and I finally have hope.

  11. Thanks very much for this post. I’ve just started LDN for Hashimoto’s. Can I ask … what was your starting dose … and what were the reasons you ended up dropping the dose later to your doctor’s recommendation? Are you taking it in tablets, capsules, or liquid?

  12. Susan Zorn says

    Thank you so much for sharing your experience. I have struggled with Hashimotos for 43 years. It is very discouraging to be treated by doctors that only have a superficial understanding of the disease. It is heartbreaking too that family fails to educate themselves about Hashimotos and draws the conclusion that the sufferer is a hypochondriac. Only recently have I learned about ldn treatment. I have been extremely encouraged to hear of your positive outcome. Your journey has helped be to make the decision to solicit the advice of professionals that are progressive and informef. I haven’t dreamed in years and am looking forward to that result. Thank you so much.

  13. jerrie Davidson says

    I took LDN, I had headaches for about a month. My doctor only kept me on LDN for 3 months and my antibodies did go down but significantly. I will insist on staying on them for 6 months which sounds like the recommended protocol with every thing else I have read. I have been fighting Hashimoto’s for 20 years. I felt wonderful the 3 months I was on LDN. Since being off of it I have reverted back to the “normal” for me. I will try again. Thankyou for sharing your story.

  14. I had migraines when I was your age. After many years I finally started putting them on my “bathroom” calendar where I kept track of my periods. Eventually I was able to see that they were connected. I got them the second day after I finished my period. That’s not the normal time to get them but after I made the connection I could predict when the next one would be. There wasn’t much they could give me back then, but nowadays there are doctors who could prescribe hormones to help. Your migraines may not be the same as mine but to be sure put them on the calendar. Even though I didn’t get relied, at least I could avoid big commitments on those days.

    • Rachel sexton says

      I am thinking of going on LDN for hashimotos as the fatigue and Brian fog days I wish it be over! I did reduce my antibodies with diet and supplements from 1,400 to 460! How long do you have to take LDN for as it’s very expensive in Ireland

  15. My dreams are so vivid, I feel like I have not rested… hoping they calm down. I am in my second or third week. I was about to quit and came across this. I will continue to try. My antibiodies are out the roof.

  16. Kathleen Bright says

    Hi Dana,
    I have had Hashimoto’s for probably decades but a recent test (less than a year ago) only determined that; before then I was being treated for Hypothyroidism. Anyway, like you I was misdiagnosed for many years and in the interim thought I was going down right crazy with mood swings, depression, anxiety…you get it…so now that I know what it is I am actually being proactive in trying to be Hashi free. My Naturopath recently put me on LDN, 4 weeks now, I started on a really low dose .05ml and have now increased it to the .3ml I am to remain on. After reading your post I am very excited to see my results in a few months! I do get a lot of morning headaches though since being on it, other than that my dreams have not changed…

  17. I have Hashimoto’s and hypothyroidism. I am on Thyroid NP 60 mcg medication. My question is, can I take LDN with it. If you know

  18. I am so sick today and I am tired of being sick and tired!!!! IBS, endometriosis, adenomiosis , chronic iritis, pituitary tumors and now hypothyroidism!!!! When does this end? How can I get help?

    • I am seeing a naturopath and she just prescribed this medication to me – if you have not seen one I highly recommend it!

  19. Kaye McClaren says

    Very curious as to LDN dosing timing. If I’m correct Bihari insited that to most effective it should be taken between 12-4am. What are/is your experiences with timing and thoughts on effectiveness if not taken at that difficult time? Thank you.

  20. How did the doctors test/diagnose your staph infection?

  21. I had the same thing happen with my thyroid antibodies. Unfortunately I had Hashimotos for over 40 years before I found LDN so lots of damage already. Am currently working with Dr to lower my NDT. I have many other autoimmune conditions so will be interested to see how they go with LDN. Thanks for sharing.

    • Hi Denice, All the best with your LDN treatment. I hear from many Hypothyroid Mom readers that rave about LDN for helping their autoimmune diseases. All the best, Hypothyroid Mom.

  22. My dad uses it for his Hashimoto’s and my husband for his MS. It’s been a game changer for both! Currently having my thyroid looked at and will be using LDN if the results come back as suspected. My husband and I recommend looking into LDN to anyone and everyone who has “something” it could help and always get weird looks, but two people in my family are free of big pharma, money making drugs (and their HORRID side effects) and living BETTER lives because of LDN. Finding a doc to treat/prescribe isn’t always easy, but worth it!

  23. Sooo…I actually have LDN. Suspect either fibro or hashis. Can’t get a doctor to test antibodies or run any kind of c reactive protein test etc for pmr. I have had reynauds for decades. I’m 49 and likely perimenopausal and in near constant muscle tension hell. My 4th chiro conceded I have no structural issue but a muscle issue he can’t figure out. Back to my their I have hashi and/or fibro.

    My question…I had genesight done. Naldextrone is tested. Annnndddd for me can up in the yellow zone so the Dr who ran that says she’s never prescribe. Basically says it’s questionable to be effective with my genes. But that is naldextrone as an anti opoid for drug use.

    Worth even trying?? I’m.so confused and stressed and tired of always being in psik and off balance as I’m so tense it throws off my balance.

  24. Happy to hear you’ve found something that works for you. I do not permit posting advertisements for particular products. That’s probably not your intention but I will delete it.

  25. Naomi Pollock says

    That sounds very exciting, but does anyone know of any doctors in Britain who would prescribe this medication?

    • Hi Naomi, The LDN Research Trust group is holding the LDN 2018 conference in Glasgow Scotland on the 7th July at Glasgow University, Wolfson Medical Building, and will be LiveStreamed around the world online for everyone. I recommend attending livestream as I am, but if that doesn’t work try looking up the various doctors listed under Speakers because several of them are located in the UK. Here is the link to the conference page: http://bit.ly/2sB2Kcm

    • A Chemisr in Glasgiw can arrange for tou to get LDN though you will he required to supply evidence of your disorder. Attached lunk below

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