300 hypothyroidism symptoms: count how many you have

300 hypothyroidism symptoms: count how many you have

The World Health Organization estimates that thyroid dysfunction affects 750 million people worldwide and the American Thyroid Association warns that up to 60 percent of those with thyroid disease are unaware of their condition.

Of the 750 million people with thyroid dysfunction, 1.3 million of them are currently following my site Hypothyroid Mom. The majority are here because they are still feeling unwell despite standard hypothyroidism treatment. Most are told their thyroid is “fine” while they struggle with a countless number of symptoms. Often times their doctors have no clue the vast array of symptoms that can befall a thyroid patient and most patients have no idea their symptoms could possibly be a red flag that their condition is not being well treated. Some may back down from speaking up to their doctor because they feel “doctor knows best” or that they don’t have any scientific proof to back up their claims…until now.

The first step before anything with hypothyroidism is to know the symptoms. There are over 300. Yes you read that correctly. Every single cell of the body requires thyroid hormone for proper functioning, so every single part of the body is vulnerable when you have abnormal thyroid function.

Of course not every single symptom you experience is caused by your thyroid. And not everyone will present with the exact same symptoms. It’s an interesting thing really how thyroid disease can present in different ways in different people.

At my lowest point with hypothyroidism when I could barely keep my eyes open through the day, I suffered from 118 symptoms on this list. I was a walking billboard for hypothyroidism, yet my doctor at that time insisted my thyroid was “normal”. Now thanks to optimal thyroid treatment including all the many pieces of the thyroid puzzle that I include at Hypothyroid Mom, the majority of my symptoms have completely disappeared. I just recently counted the number of symptoms that I experience and I only have 9 left that persist but even then most of the 9 are greatly improved.

If you are experiencing a high number of the symptoms on this list, then this is your big red flag (and I’m waving it wildly at you).

I have spent more days than you can imagine creating this article, carefully putting together a list of scientific studies on the bottom of the article to back up the symptoms on this list. I hope this article above all others at Hypothyroid Mom passes the power into your hands. Your symptoms are not all in your head. No, you are not crazy or lazy or faking, even if other people make you feel that way. Convincing yourself of this can change your world.

Even if your current doctor refuses to help, you will know without a shadow of a doubt that you need to find an open-minded thyroid doctor. Even if that means firing 10 doctors until you find the one that helps.

Now let’s get started and don’t forget to count the number of symptoms that you experience as you go through the list of 306.

I know this is a seriously long list, but getting that final score may very well shock you and (my great hope) spur you into the biggest wellness journey of your life. Remember to count your symptoms again over time to track your improvements as you learn more about effective thyroid treatments at Hypothyroid Mom.

You may be wondering how to print this article or any other article at Hypothyroid Mom. Go to the article you wish to print, then select File then Print or type command P. This will open a printing window where you select your settings and print.

Energy & Hypothyroidism

Excessive daytime sleepiness

Unusually long periods of sleep at night

Slow recovery after exercise

Insomnia

Narcolepsy

Need to nap

Weakness

Fatigue after waking

Metabolism & Hypothyroidism

Weight gain

Inability to lose weight

Ascites (buildup of fluid in abdomen)

Swelling

Accumulation of thick, heavy fat

Lymphedema

Cellulite

Weight loss

Increased appetite

Decreased appetite

Obesity

Body Temperature & Hypothyroidism

Freezing hands

Freezing feet

Cold sweats

Intolerance to cold

Intolerance to heat

Skin hot or cold to the touch

Night sweats

Shivering episodes

Clammy hands

Excessing sweating

Decreased sweating

Low basal body temperature

High basal body temperature

Increased risk of hypothermia

Susceptibility to Infections & Hypothyroidism

Colds

Flu

Pneumonia

Tuberculosis

Slow infection recovery

Sinus infections

Skin infections

Ear infections

H. Pylori

Epstein-Barr Virus

Candida (yeast)

Onychomycosis

Athlete’s Foot

Urinary tract infections

Bladder infections

Poly-Autoimmunity & Hypothyroidism

Addison’s Disease

Alopecia Areata

Celiac Disease

Chronic Urticaria

Graves’ Disease

Hashimoto’s Thyroiditis

Lichen Planus

Multiple Sclerosis

Pernicious Anemia

Premature Ovarian Failure

Psoriasis

Raynaud’s Disease

Rheumatoid Arthritis

Sarcoidosis

Scleroderma

Sjögren’s Syndrome

Systemic Lupus Erythematosus

Type 1 Diabetes

Vitiligo

Oral Cavity & Hypothyroidism

Macroglossia (enlargement of tongue)

Glossitis (inflammation of tongue)

Tongue with scalloped edges

Dysgeusia (altered sense of taste)

Mouth breathing

Retention of primary teeth

Delayed or absent eruption of permanent teeth

Malocclusion (misalignment of teeth)

Salivary gland enlargement

Susceptibility to periodontal disease

Bleeding gums

Swollen gums

Receding gums

Susceptibility to cavities

Enamel hypoplasia (pits, spots, grooves in enamel)

Burning mouth

Dry mouth

Tooth sensitivity

Bad breath

Ears & Hypothyroidism

Tinnitus

Ringing ears

Vertigo

Dizziness

Balance problems

Meniere’s disease

Pressure in ears

Itchy ears

Dry, scaly ear canal

Excess wax in ear canal

Hearing loss

Eyes & Hypothyroidism

Dry eyes

Eyelid puffiness

Eye irritation

Eye protrusion

Ptosis (drooping of eyelid)

Eyelid twitches

Diplopia (double vision)

Impaired color contrast sensitivity

Noninfectious uveitis (inflammation of eye)

Glaucoma

Cataracts

Yellowing of the whites of eyes

Xanthelasma (yellow bumps around eyelids)

Hair & Hypothyroidism

Hair loss

Dry hair

Frizzy hair

Brittle hair

Coarse hair

Fine hair

Dry, flaky, itchy scalp

Scalp redness

Baldness

Premature gray hair

Loss of eyelashes

Loss of outer third of eyebrows

Hair loss on rest of body

Extremities & Hypothyroidism

Gait abnormality (pattern of walking)

Slow tendon reflex relaxation time

Dry, flaky, cracked feet

Calluses

Palmoplantar keratoderma (thickening of soles of feet or palms of hands)

Slow nail growth

Thick, dry, cracked, brittle nails

Longitudinal ridges on nails

Absent lunulae (half moons)

Onycholysis (separation of nail from nail bed)

Spoon nails (koilonychia)

Clubbing of fingers and toes

Skin & Hypothyroidism

Dry skin

Pruritus (itchy skin)

Eczema

Melasma

Skin tags

Easy bruising

Slow wound healing

Acne

Yellow skin

Pale skin

Lichen sclerous (itchy white patches on genitals or other body part)

Numbness, tingling, pins and needles sensation

Digestive System & Hypothyroidism

Constipation

Diarrhea

IBS

Colonic diverticula

Anal fissure

Hiatal hernia

Dysphagia (difficulty swallowing)

Sensation of food being stuck in the neck

Dyspepsia (indigestion)

Bloating

Abdominal discomfort

Megacolon (abnormal dilation of colon)

Gastrointestinal bleeding

Common bile duct stones

Gallbladder stones

Reduced bilirubin excretion

Nonalcoholic fatty liver disease

Gastroesophageal Reflux GERD

Elevated liver enzymes

Liver cirrhosis

Chronic active hepatitis

Primary biliary cirrhosis

Chronic liver disease

Reduced bile flow

Hypotonia of gallbladder

Chronic gallbladder disease

Pancreas islet damage

Chronic pancreatitis

Impaired insulin secretion

Diabetes

Pain & Hypothyroidism

Body ache

Myalgia (muscle pain)

Muscle cramps

Arthralgia (joint pain)

Shoulder pain

Neck pain

Low back pain

Arthritis

Carpal tunnel syndrome

Tarsal tunnel syndrome

Adhesive capsulitis (frozen shoulder)

Spontaneous rupture of tendons

Dupuytren’s contracture (finger permanently bent into your palm)

Trigger finger (locking when you bend your finger)

Myopathy

Limited joint mobility

Fibromyalgia

Tendinitis

Chronic headache

Migraine

Restless leg syndrome

Plantar fasciitis

Gout

Peripheral neuropathy

Temporomandibular disorder

Reproductive System & Hypothyroidism

Diminished libido

Hypomenorrhea (light menstrual bleeding)

Menorrhagia (heavy menstrual bleeding)

Metrorrhagia (bleeding beyond normal 3 to 5 days)

Intermenstrual bleeding (bleeding between periods)

Polymenorrhea (menstrual cycle less than 21 days)

Oligomenorrhea (menstrual cycle greater than 35 days)

Polymenorrhagia (heavy frequent periods)

Painful periods

Amenorrhea (missing 3 periods in a row)

Anovulation (lack of ovulation)

Infertility

Miscarriage

Stillbirth

Premature delivery

Low birth weight

Fetal distress in labor

Placental abruption (placenta separates early from uterus)

Preeclampsia (high blood pressure and protein in urine in pregnancy)

Gestational diabetes (high blood sugar in pregnancy)

Postpartum hemorrhage

Precocious or delayed puberty

Premature menopause

Endometriosis

Uterine leiomyomas (fibroids)

Benign breast disease

Polycystic ovary syndrome (PCOS)

Brain & Hypothyroidism

Depression

Postpartum depression

Anxiety

Mania

Bipolar

Poor memory

Cognitive dysfunction

Impaired concentration

ADD/ADHD

Seasonal affective disorder

Phobia

Altered mood

Suicide

Aggression

OCD

Psychosis

Schizophrenia

Urinary System & Hypothyroidism

Reduced glomerular filtration rate

Decreased urinary concentrating ability

Elevated serum creatinine

Elevated serum urea

Increased 24-hour urine protein

Hyponatremia (low sodium in blood)

Decreased cystatin C

Chronic kidney disease

Glomerular disease

Nephrotic syndrome

Rhabdomyolysis

Reduced or increased voiding frequency

Decreased water load excretion

Urinary incontinence

Interstitial cystitis

Kidney failure

Respiratory System & Hypothyroidism

Pain in lower neck

Hoarse voice

Speech disorders

Breathlessness

Goiter

Chest wheezes

Chest pain

Tuberculosis

Pneumonia

Asthma

Increased sensitivity of the cough reflex

Hypoventilation (reduced breaths per minute)

Increased sputum production

Hypoxia (low oxygen in blood)

Pulmonary congestion

Hypercapnia (too much carbon dioxide in blood)

Sleep apnea

Snoring

Pleural effusion

Respiratory muscle weakness

Diaphragm weakness

Impaired exercise capacity

Chronic obstructive pulmonary disease

Pulmonary edema

Pulmonary fibrosis

Interstitial lung disease

Respiratory failure

Cardiovascular System & Hypothyroidism

Slow or fast heart rate

High or low blood pressure

High cholesterol

Pulmonary hypertension

Pericardial effusion

Pericarditis

Cardiomyopathy

Coronary artery disease

Atrioventricular block

Angina (chest pain)

Pericarditis

Atrial fibrillation

Enlarged heart

Cardiac tamponade

Mitral valve prolapse

Stroke

Heart attack

Congestive heart failure

How many symptoms did you count?

Your Total Hypothyroidism Symptoms Score:

______ / 306

Are you shocked?

I knew you would be.

Hypothyroidism Symptoms in Recent Scientific Literature:

Energy

Chaker, L., et al. Hypothyroidism. Lancet. 2017 Sep 23;390(10101):1550-1562.

Cohen, A., et al. Comorbidities in a community sample of narcolepsy. Sleep Med. 2018 Mar;43:14-18.

Dunn, D., Turner, C. Hypothyroidism in Women. Nurs Womens Health. 2016 Feb-Mar;20(1):93-8.

Louwerens, M. et al. Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism. Eur J Endocrinol. 2012 Dec;167(6):809-15.

Sethi, B., et al. The Thyroid Registry: Clinical and Hormonal Characteristics of Adult Indian Patients with Hypothyroidism. Indian J Endocrine Metab. 2017 Mar-Apr;21(2):302-307.

Metabolism

Khalid, S., et al. Myxedema Ascites: A Rare Presentation of Uncontrolled Hypothyroidism. Cureus. 2016 Dec;8(12):e912.

Laurberg, P., et al. Thyroid Function and Obesity. Eur Thyroid J. 2012 Oct;1(3):159-167.

Mullur, R., et al. Thyroid Hormone Regulation of Metabolism. Physiol Rev. 2014 Apr;94(2):355-382.

Neki, N.S. Pitting Edema in Hypothyroidism. JIMSA. 2013 Apr-Jun;26(2):133.

Witkowska-Sędek, E., et al. Thyroid dysfunction in obese and overweight children. Endokrynol Pol. 2017;68(1):54-60.

Body Temperature

Charoenpong, P., et al. 1343: Hypothermia as a presentation of hypothyroidism. Critical Care Medicine. 2013 Dec;4(12):A347.

Obermeyer, Z., et al. Individual differences in normal body temperature: a longitudinal big data analysis of patient records. BMJ. 2017 Dec 13;359:j5468.

Warner, A., et al. Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1. Proc Natl Acad Sci USA. 2013 Oct 1;110(40):16241-6.

Warner, A., Mittag, J. Brown fat and vascular heat dissipation. Adipocyte. 2014 Jul 1; 3(3): 221–223.

Susceptibility to Infections

Chetambath, R., et al. Severe pneumonia in a young female with a possible causal relationship to hypothyroidism – A case report and review of literature. IJMAR. 2017;2(2):17-24.

Dittfeld, A., et al. A possible link between the Epstein-Barr virus infection and autoimmune thyroid disorders. Cent Eur J Immunol. 2016;41(3):297-301.

Günel, C., et al. [The relationship between hypothyroidism and rhinitis]. Kulak Burun Bogaz Ihtis Derg. 2010 Jul-Aug;20(4):163-8.

Hou, Y., et al. Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases. Oncotarget. 2017 Dec 29;8(70):115691-115700.

Khan, Q., et al. Prevalence of Hepatitis B and C infection in autoimmune thyroid patients. Journal of Entomology and Zoology Studies. 2017;5(2):1335-1337.

Macura. A.B., et al. [Nail susceptibility to fungal infections in patients with hypothyroidism and hyperthyroidism]. Przegl Lek. 2005;62(4):218021.

Nóbrega, M.M., et al. Bacteriuria and urinary tract infection after female urodynamic studies: risk factors and microbiological analysis. Am J Infect Control. 2015 Oc 1;43(10):1035-9.

Ren, H., et al. The non-thyroidal illness syndrome is associated with postoperative surgical site infections in enterocutaneous fistulae. Int J Surg. 2018 Feb 7;51:213-217.

Sajid, K.M., et al. Thyroid function in pulmonary tuberculosis. J Coll Physicians Surg Pak. 2006 Oct;16(10):633-6.

Poly-Autoimmunity

Anaya, J.M., et al. Sjögren’s Syndrome and Autoimmune Thyroid Disease: Two Sides of the Same Coin. Clin Rev Allergy Immune. 2018 Sep 5.

Anoop, J., et al. Unravelling thyroid dysfunction in rheumatoid arthritis: History matters. Int J Rheum Dis. 2018 March;21(3):688-692.

Barmpari, M.E., et al. Thyroid Dysfunction among Greek Patients with Type 1 and Type 2 Diabetes Mellitus as a Disregarded Comorbidity. J Diabetes Res. 2017;2017:6505814.

Bliddal, S., et al. Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Res. 2017;6:1776.

Edwards, N.C., et al. Comorbidity in US patients with multiple sclerosis. Patient Relat Outcome Meas. 2018 Feb 13;9:97-102.

Li, D., et al. The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis. Front Endocrinol (Lausanne): 2017;8:310.

Norström, F., at al. The Impact of Thyroid Autoimmunity on Thyroid function in 12-year-old Children with Celiac Disease. J Pediatr Gastroenterol Nutr. 2018 Jan 25.

Perga, S., et al. The Footprints of Poly-Autoimmunity: Evidence for Common Biological Factors Involved in Multiple Sclerosis and Hashimoto’s Thyroiditis. Front Immunol. 2018;9:311.

Robazzi, T.C.M.V., Adan, F.F. Autoimmune thyroid disease in patients with rheumatic diseases. Rev Bras Reumatol. 2012;52(3):423-430.

Schneider, L.K. Multiple Autoimmune Syndrome on the Rise, Clinical Vigilance Needed. EndocrineWeb.

Solanki, K.K., et al. High Prevalence of Antithyroid Antibodies in a New Zealand Cohort of Patients with Systemic Sclerosis. J Clin Rheumatol. 2018 Feb 15.

Vachiramon, V., et al. Prevalence of Thyroid Abnormalities in Thai Patients with Vitiligo. Biomed Res Int. 2017;2017:7502935.

Oral Cavity

Chandna, S., Gathla, M. Oral manifestations of thyroid disorders and its management. Indian J Endocrinol Metab. 2011 Jul;15(Suppl2):S113-S116.

Costa, C., et al. A systemic disease un…suspected by physical examination. BMJ Case Report. 2014 Oct 9;2014.

Dudhia, S.B., Dudhia, B.B. Undetected hypothyroidism: A rare dental diagnosis. J Oral Maxillofac Pathol. 2014 May;18(2):315-9.

Femiano, F., et al. Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jan;105(1):e22-7.

Grozdinska, A., et al. Prevalence of temporomandibular disorders in patients with Hashimoto thyroiditis. Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Gupta, R., et al. Oral Manifestations of Hypothyroidism: A Case Report. J Clin Diagn Res. 2014 May;8(5):ZD20-ZD22. 2018 Jul;79(4):277-288.

Kothiwale, S., Panjwani, V. Impact of thyroid hormone dysfunction on periodontal disease. Journal of The Scientific Society. 2016. 43(1):34-37.

Li, D., et al. The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis. Front Endocrine (Lausanne). 2017 Nov 9;8:310.

Naik, M.M., Vassandacoumara, V. Qualitative and quantitative salivary changes and subjective oral dryness among patients with thyroid dysfunction. Indian J Dent Res. 2018 Jan-Feb;29(1):16-21.

Tong, H.J., et al. Management of a child with severe hypodontia in the mixed dentition stage of development. Our Arch Paediatr Dent. 2014 Dec;15(6):449-54.

Venkatesh Babu, N.S., Patel, P.B. Oral health status of children suffering from thyroid disorders. J Indian Soc Pedod Prev Dent. 2016 Apr-Jun;34(2):139-44.

Wémeau, J.L., et al. [Oral and dental expression of thyroid diseases]. Presse Med. 2017 Sep;46(9):864-868.

Zahid, T.M., et al. The Effects of Thyroid Hormone Abnormalities on Periodontal Disease Status. Journal of the International Academy of Periodontology. 2011;13(3):80-85.

Ears

Andrade, C.L.O., et al. Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review. Arch Endocrine Metab. 2017 Setp-Oct;61(5):501-505.

Fayyaz, B., Upreti, S. Autoimmune inner ear disease secondary to Hashimoto’s thyroiditis: a case report. J Community Hosp Intern Med Prospect. 2018;8(4):227-229.

Karakus, C.F., et al. Is sensorineural hearing loss related with thyroid metabolism disorders. Indian Journal of Otology. 2015;21(2):138-143.

Kim, H.J., et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015 May 28;10(5):e0127578.

Lichtenberger-Geslin, L., et al. Factors Associated with Hearing Impairment in Patients with Congenital Hypothyroidism Treated Since the Neonatal Period: A National Population-Based Study. JCEM. 2013 Sep 1;98(9):3644-3652.

Messina, A., et al. Italian survey on benign paroxysmal positional vertigo. Acta Otorhinolaryngol Ital. 2017 Aug;37(4):328-335.

Orhan, I., et al. Tympanometric changes and eustachian tube function in patients with hypothyroidism. J Craniofac Surg. 2014 May;25(3):e230-3.

Santosh, U.P., Rao, M.S. Incidence of Hypothyroidism in Meniere’s Disease. J Clin Diagn Res. 2016 May;10(5):MC01-3.

Wojtczak, R., et al. Epidemiology of dizziness in northern Poland – The first Polish neurootologic survey of the general population. Ann Agric Environ Med. 2017 Sep 21;24(3):502-506.

Eyes

Ajith, T.A., et al. Association of Hypothyroidism with Glaucoma: A Recent Update: ARC Journal of Ophthalmology. 2016;1(1):23-27.

Cakir, M., et al. The Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Study. Eur Thyroid J. 2015 Mar;4(1):43-47.

Choi, H.Y., et al. Recurrent oculomotor neuritis related to autoimmune hypothyroidism. Case Report. Neuro Endocrinol Lett. 2015;36(4):303-5.

Jain, D., et al. A Case Report on Severe Hypothyroidism Associated with Complete Bilateral Ptosis: A Rare Presentation. Journal of the ASEAN Federation of Endocrine Societies. 2016 May;31(1):65.

Ju, C., Zhang, L. Diplopia in a patient with Hashimoto’s thyroiditis: A case report and literature review. Medicine (Baltimore). 2017 Jun;96(26):e7330.

Kan, E., et al. Presence of Dry Eye in Patients with Hashimoto’s Thyroiditis. Journal of Ophthalmology. 2014. vol. 2014, Article ID 754923, 4 pages.

Laftah, Z., Al-Naimi, F. Xanthelasma: An update on treatment modalities. J Cutan Aesthet Surg. 2018;11:1-6.

Mahto, R.S. Ocular features of hypothyroidism. Brit J Ophthalmology. 1972;56:546.

Rosenblatt, A., et al. Association Between Non-Infectious Uveitis and Thyroid Dysfunction: A Case Control Study. Thyroid. 2017 Jun 1;27(6):757-761.

Wang, S., et al. Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis. PLoS One. 2017 Oct 25;12(10):e0186634.

Hair

Bin Saif, G.A. Severe subtype of alopecia areata is highly associated with thyroid autoimmunity. Saudi Med J. 2016 Jun;37(6):656-61.

Contreras-Jurado, C., et al. Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors. PLoS One. 2014;9(9):e108137.

Contreras-Jurado, C., et al. Thyroid hormone signaling controls hair follicle stem cell function. Mol Biol Cell. 2015 Apr 1;26(7):1263-72.

Siah, T.W., et al. Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Int J Trichology. 2016 Apr-Jun;8(2):57-61.

Wolff, H., et al. The Diagnosis and Treatment of Hair and Scalp Diseases. Dtsch Arztebl Int. 2016 May 27;113(21):377-86.

Extremities

Aishwarya, K., et al. Clinical Signs in Hypothyroidism – Myoedema and Woltman Sign. QJM. 2017 Nov 28.

Bano, A., et al. Gait patterns associated with thyroid function: The Rotterdam Study. Sci Rep. 2016 Dec 14:6:38912

Krishnamurthy, A., et al. Clinical signs in hypothyroidism – myxoedema and Woltman sign. QJM: An International Journal of Medicine. 2018 Mar;111(3):193.

Mathur, S.K., et al. Clubbing in a Case of Hypothyroidism. JAPI. 2008. 56.:241.

Razi, A., et al. Evaulation of dermal symptoms in hypothyroidism and hyperthyroidism. Pak J Biol Sci. 2013 Jun 1;16(11):541-4.

Skin

Al-Arashi, W., et al. [A man who was unable to open his eyes]. Ned Tijdschr Geneeskd. 2018;162(0):D2176.

Couto, J.A., et al. Nodular Foot Myxedema Masquerading as Lymphedema. Plastic and Reconstructive Surgery – Global Open. 2015 Jul;3(7):e457.

Firouzi, A., et al. The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model. J Lasers Med Sci. 2018 Winter;9(1):7-10.

Haritha, S., Kirthi Sampath, K. Skin Manifestations of Hypothyroidism-A Clinical Study. Journal of Dental and Medical Sciences. 2013 May-Jun;7(2):58-60.

Lause, M., et al. Dermatologic manifestations of endocrine disorders. Transl Pediatr. 2017 Oct;6(4):300-312.

Keen, M.A., et al. A Clinical Study of the Cutaneous Manifestations of Hypothyroidism in Kashmir Valley. Indian J Dermatol. 2013 Jul-Aug;58(4):326.

Mogaddam, M.R., Alamdari, M.I., Maleki, N. Ardabili, N. Abedkouhi, S. Evaluation of auotimmune thyroid disease in melasma. J Cosmet Dermatol. 2015 Jun;14(2):167-71.

Pal, B. Paraesthesia. BMJ. 2002 Jun 22;324(7352):1501.

Platsidaki, E., et al. The Association of Various Metabolic Parameters with Multiple Skin Tags. J Clin Aesthet Dermatol. 2018;11(10):40-43.

Safer, J.D. Thyroid hormone action on skin. Dermatoendocrinol. 2011 Jul-Sep;3(3):211-215.

Safer, J.D. Thyroid Hormone and Wound Healing. J Thyroid Res. 2013;2013:1234538.

Sharma, R.K., et al.  Study of Thyroid Function in Housewives with Chronic and Relapsing Hand Eczema. IJIRMS. 2017 Feb;02(02):592-594.

Stewart, T.J., Bazergy, C. Thyroid autoimmunity in female post-adolescent acne: A case-control study. Dermatoendocrinol. 2017 Dec 12;9(1):e1405198.

Takir, M., et al. Skin findings in autoimmune and non autoimmune thyroid disease with respect to thyroid functional status and healthy controls. Turk J Med Sci. 2017 Jun 12;47(3):764-770.

Talaee, R., Ghafarpasand, I., Masror, H. The Relationship Between Melasma and Disturbances in the Serum Level of Thyroid Hormones and Indices. Open Science. 2015;2(2):19-23.

Thachil, J., et al. Management of hypothyroidism in adults. Response: Look for hypothyroidism in women with easy bruising. BMJ. 2008;337:a801. Retrieved from: https://www.bmj.com/rapid-response/2011/11/02/look-hypothyroidism-women-easy-bruising

Vergou, T., Mantzou, E., Tseke, P., Moustou, A.E., Katsambas, A., Alevizaki, M., Antoniou, C. Association of thyroid autoimmunity with acne in adult women. J Eur Acad Dermal Venereol. 2012 Apr;26(4):413-6.

Digestive System

Akyüz, F., Mutluay Soyer, Ö. Which diseases are risk factors for developing gastroesophageal reflux disease? Turk J Gastroenterol. 2017 Dec;28(Supplement 1):S44-S47.

Carter, D., et al. The Severity of Symptoms Related to Irritable Bowel Syndrome is a Risk Factor for the Misclassification of Significant Organic Disease. J Clin Gastroenterol. 2016 June 24.

Chen, C., et al. The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology. International Journal of Endocrinology. 2018, vol. 2018, Article ID 2861034, 14 pages.

Chogle, A., Saps, M. Yield and cost of performing screening tests for constipation in children. Can J Gastroenterol. 2013 Dec;27(12):e35-8.

Duong, N., et al. Case of acute mixed liver injury due to hypothyroidism. BMJ Case Rep. 2018 Jan 23;2018.

Filik, L., Aktas, M.N. Is there a Link between Colonic Diverticula and Thyroid Disorder? Gastroenterology & Hepatology: Open Access. 2016;5(7).

Harbuwono, D.S., et al. Improvement of Metabolic Parameters Resulted from Levothyroxine Therapy in Hypothyroid Type 2 Diabetes Mellitus Patient. Acta Med Indones. 2016 Apr;48(2):145-7.

He, W., et al. Relationship between Hypothyroidism and Non-Alcoholic Fatty Liver Disease: A Systemic Review and Meta-analysis. Front Endocrine (Lausanne). 2017 Nov 29;8:335.

İlhan, M., et al. Esophagus motility in overt hypothyroidism. J Endocrinol Invest. 2014 Jul;37(7):639-44.

Khoja, H.R., et al. Prevalence of Subclinical Hypothyroidism in Gall Bladder tone and CBD Stone Disease Patients – A Three Year Study. International Journal of Scientific Research. 2018;7(5):38-41.

Komatsu, K., et al. High prevalence of hypothyroidism in patients with autoimmune pancreatitis. Dig Dis Sci. 2005 Jun;50(6):1052-7.

Kopylov, U., et al. Obesity, metabolic syndrome and the risk of development of colonic diverticulosis. Digestion. 2012;86(3):201-5.

Laukkharinen, J., et al. The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones-a review. HPB Surg. 2012;2012:102825.

Laukkarinen, J., et al. Bile duct stone procedures are more frequent in patients with hypothyroidism. A large, registry-based, cohort study in Finland. Scandinavian Journal of Gastroenterology. 2010;45(1).

Mapel, D.W., et al. The epidemiology and treatment of anal fissures in a population-based cohort. BMC Gastroenterol. 2014 Jul 16;14:129.

Nomura, M. Association of Symptoms of Gastroesophageal Reflux with Metabolic Syndrome Parameters in Patients with Endocrine Disease. ISRN Gastroenterol. 2014;2014:863206.

Oh, R.C., et al. Mildly Elevated Liver Transaminase Levels: Causes and Evaluation. Am Fam Physician. 2017 Dec 1;96(11):709-715.

Ozair, M., et al. Prevalence of thyroid disorders in North Indian Type 2 diabetic subjects: A cross sectional study. Diabetes Metab Syndr. 2017 Dec 20. pii: S1871-4021(17)30421-6.

Răcătăianu, N., et al. Thyroid disorders in obese patients. Does insulin resistance make a difference? Arch Endocrinol Metab. 2017 Dec;61(6):575-583..

Rodriguez Lugo, D.A., et al. [Primary biliary cholangitis. Part 1. State of the art, epidemiology, physiopathology and clinical manifestations]. Rev. Gastroenterol Peru. 2017 Oct-Dec;37(4):357-364.

Savina, L.V., et al. [Hiatus hernia and gastroesophageal reflux disease as a manifestation of a newly revealed hypothyroidism]. Klin Med (Mosk). 2006;84(2):71-4.

Shabanzadeh, D.M., et al. Screen-detected gallstone disease and autoimmune diseases – A cohort study. Dig Liver Dis. 2018 Jan 31. pii: S1590-8658(18)30141-5.

Shizuma, T. Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review. Biomed Res Int. 2016;2016:5187061.

Sinha, R.A., et al. Direct effects of thyroid hormones on hepatic lipid metabolism. Nat Rev Endocrine. 2018 Feb 23.

Subekti, I., et al. Thyroid Dysfuntion in Type 2 Diabetes Mellitus Patients. Acta Med Indones. 2017 Oct-49(4):314-323.

Pain

Alakes, K.K., et al. Rheumatic manifestations in primary hypothyroidism. Indian Journal of Rheumatology. March 2013;8(1):8-13.

Brooks, L., et al. Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue? J Pain REs. 2015 Aug 20;8:561-9.

Cakir, M., et al. Musculoskeletal manifestations in patients with thyroid disease. Clinical Endocrinology. Sep 2003;59(2):162-7.

Eslamian, F., et al. Electrophysiologic Changes in Patients with Untreated Primary Hypothyroidism. Journal of Clinical Neurophysiology. June 2011;28(3):323-328.

Evans, R.W., Timm, J.S. New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated with Thyroid Disease. Headache. 2017 Feb;57(2):285-289.

Haliloglu, S., et al. Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity. Clin Rheumatol. 2017 Jul;36(7):1617-1621.

Hezarkhani, S., et al. Rheumatologic manifestations in Iranian patients with autoimmune thyroid diseases. J Clin Diagn Res. 2014 Oct;8(10):MC06-8.

Joshi, R., et al. Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity. Sage Journals. 20 Jan 2016;47(1):2017.

Kame, S.S., Bhalerao, N.S. Carpal Tunnel Syndrome in Hypothyroidism. J Clin Diagn Res. 2016 Feb;10(2):OC36-8.

Oliva, F., et al. Thyroid hormones enhance growth and counteract apoptosis in human tenocytes isolated from rotator cuff tendons. Cell Death Dis. 313;4(7):705.

Pantazis, K., et al. Spontaneous rupture of the long head of the biceps tendon in a woman with hypothyroidism: a case report. Journal of Medical Case Reports. 2016;10:2.

See, L.C., et al. Hyperthyroid and hypothyroid status was strongly associated with gout and weakly associated with hyperuricaemia. PLoS One. 2014 Dec 8;9(12):e114579.

Song, H.S., et al. Association between temporomandibular disorders, chronic diseases, and ophthalmologic and otolaryngology disorders Korean adults: A cross-sectional study. PLoS One. 2018 Jan 31;13(1):e0191336.

Tan, E.K., et al. Restless legs symptoms in thyroid disorders. Parkinsonism Relat Disord. 2004 Mar;10(3):149-51.

Reproductive System

Ajmani, N.S., et al. role of Thyroid Dysfunction in Patients with Menstrual Disorders in Tertiary Care Center of Walled City of Delhi. J Obstet Gynaecol India. 2016 Apr;66(2):115-9.

Anil, C., et al. The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto’s thyroiditis. J Endocrinol Invest. 2015 Sep;38(9):971-5.

Deshmukh, P.Y., et al. The association of thyroid disorders with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2015 Jun;4(3):701-708.

Digra, M., et al. Thyroid profile in women with menstrual disorders. Int J Reprod Contracept Obstet Gynecol. 2017 Aug;6(8):3300-3305.

Getahun, D., et al. Association between maternal hypothyroidism and autism spectrum disorders in children. Pediatr Res. 2017 Dec 15.

Ghaemi, N., et al. Precocious Puberty: An Unusual Presentation of Hypothyroidism. International Journal of Pediatrics. 2013 Dec;1(2):51-54.

Jing, S., et al. Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness. Reprod Biol Endocrinol. 2011;9:119.

Kim, M.H., et al. The relationship between thyroid nodules and uterine fibroids. Endocr J. 2010;57(7):615-21.

Kowalczyk, K., et al. Thyroid disorders in polycystic ovary syndrome. Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):346-360.

Krassas, G.E., et al. Thyroid Function and Human Reproductive Health. Endocrine Reviews. 2010 Oct 1;31(5):702-755.

López-Tinoco, C., et al. Impact of positive thyroid autoimmunity on pregnant women with subclinical hypothyroidism. Endocrinol Diabetes Nutr. 2018 Jan 6.

Mansourian, A.R. Female reproduction physiology adversely manipulated by thyroid disorders. a review of literature. Pak J Biol Sci. 2013 Feb 1;16(3):112-20.

Martinez, M., et al. Hypothyroidism during pregnancy and its association to perinatal and obstetric morbidity: a review. Endocrinol Diabetes Nutrients. 2018 Feb;65(2):107-113.

Miranda, A., Sousa, N. Maternal hormal milieu influence on fetal brain development. Brain Behav. 2018 Jan 24;8(2):e00920.

Okeke, T.C., et al. Premature Menopause. Ann Med Health Sci Res. 2013 Jan-Mar;3(1):90-95.

Osman, H.A., et al. Precocious puberty: An experience from a major teaching hospital in Central Saudi Arabia. Sudan J Paediatr. 2017;17(1):19-24.

Ott, J., et al. Overt hypothyroidism is associated with the presence of uterine leiomyoma: a retrospective analysis. Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:19-22.

Patel, N., Kashanian, J.A. Thyroid Dysfunction and Male Reproductive Physiology. Semin Reprod Med. 2016 Nov;34(6):356-360.

Rajiwade, S.R., et al. Endocrine Abnormalities in Adolescents with Menstrual Disorders. J Obstet Gynaecol India. 2018 Feb;68(1):58-64.

Rawal, S., et al. A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. JCEM. 2018 Jul 1;103(7):2447-2456.

Sinaii, N., et al. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Human Reproduction. 2022 Oct;17(10):2715-2724.

Singla, R., et al. Thyroid disorders and polycystic ovary syndrome: An emerging relationship. Indian J Endocrinol Metab. 2015 jan-Feb;19(1):25-29.

Smith, A., et al. Thyroid disorder in pregnancy and postpartum. Just Prescribed. 2017 Dec;40(6):214-219.

Thompson, W., et al. Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopment disorders in offspring. A systematic review and meta-analysis. Clin Endocrinol (Oxf). 2018 Jan 11.

Tudosa, R., et al. Maternal and fetal complications of the hypothyroidism-related pregnancy. Maedica (Buchar). 2010 Apr;5(2):116-123.

Brain

Abd El Rahman, S., et al. Thyroid dysfunction in attention-deficit hyperactivity disorder and effect of comorbidity. Egypt J Psychiatr. 2014;35:89-94.

Agachanli, R., et al. Psychosis related with Hashimoto thyroiditis: a case report. Düşünen Adam The Journal of Psychiatry and Neurological Sciences. 2016 Jun;29(2):181-6.

Alex, C., Kumar, R. An interesting case of Myxedema Mania – A case report. RGUHS Med Sciences. 2015;5(1):27-29.

Al-Mendalawi, M. Encephalopathy associated with autoimmune thyroid disease in an 11-year-old girl, a rare clinical presentation. Thyroid Research and Practice. 2017;14(3):133.

Bathla, M., et al. Prevalence of anxiety and depressive symptoms among patients with hypothyroidism. Indian J Endocrinol Metab. 2016 Jul-Aug;20(4):468-474.

Brockington, I. Non-reproductive triggers of postpartum psychosis. Arch Womens Ment Health. 2017;20:61.

Calzà, L., et al. Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair. Vitam Horm. 2018;106:253-281.

Capetillo-Ventura, N., Baeza, I. Psychiatric Symptoms due to Thyroid Disease in a Female Adolescent. Case Rep Endocrinol. 2014;2014:972348.

DAS, S., et al. Autoimmune Thyroiditis Presenting as Psychosis. Shanghai Arch Psychiatry. 2017;29(3):174-176.

Dold, M., et al. Clinical correlates of augmentation/combination treatment strategies in major depressive disorder. Acta Psychiatr Scand. 2018 Feb 28.

Feldman, A.Z., et al. Neuropsychiatric Manifestations of Thyroid Disease. Endocrinol Metab Clin N Am. 2013;42:453-476.

Hage, M.P., Azar, S.T. The Link between Thyroid Function and Depression. Journal of Thyroid Research. 2012, vol. 2012, Article ID 590648, 8 pages.

Kandukuri, R.C., et al. Nonadherence to Medication in Hypothyroidism. A Case Report. Prim Care Companion J Clin Psychiatry. 2010;12(3):PCC.09m00863.

Kapoor, N., Couch, J. A Case of Hashimoto’s Encephalopathy treated with only Oral Thyroid medication and symptomatic therapy for seizures and psychosis, but Without Steroids (P2.257). Neurology. Apr 2016;86(16 Supplement):P2.257.

Khurshid, S., et al. Changes in thyroid function status of suicidal patients. Arch Clin Psychiatry (São Paulo). 2018 Jan/Feb;45(1):12-14.

Lazaro, P.C.F., et al. Psychosis associated with methimazole-induced hypothyroidism: a case report. J. bras. psiquiatr. 2013;62(2):171-3.

Mavroson, M.M., et al. Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. J Am Osteopath Assoc. 2017 Jan 1;117(1):50-54.

Nazou, M., et al. [Psychotic episode due to Hashimoto’s thyroiditis]. Psychiatriki. 2016 Apr-Jun;27(2):144-7.

Pandey, V.P., et al. Verbal Episodic Memory in Young Hypothyroid Patients. Indian J Endocrine Metab. 2017 Nov-Dec;21(6):812-814.

Parikh, N., et al. A case report on myxedema madness: curable psychosis. Indian J Psychol Med. 2014 Jan;36(1):80-1.

Samuels, M.H. Psychiatric and cognitive manifestations of hypothyroidism. Cure Open Endocrinol Diabetes Obesity. 2014 Oct;21(5):377-383.

Santos, N.C., et al. Revisiting Thyroid Hormones in Schizophrenia. J Thyroid Res. 2012;2012:569147.

Sierra, P., et al. What is the real significance and management of major thyroid disorders in bipolar patients? Rev Psiquiatr Salud Ment. 2014 Apr-Jun;7(2):88-95.

Szlejf, C., et al. Thyrotropin level and cognitive performance: Baseline results from the ELSA-Brasil Study. Psychoneuroendocrinology. 2018 Jan;87:152-158

Tayde, P.S., et al. Hypothyroidism and Depression: Are Cytokines the Link? Indian J Endocrine Metab. 2017 Nov-Dec;21(6):886-892.

Ueno, S., et al. Acute psychosis as an initial manifestation of hypothyroidism: a case report. J Med Case Rep. 2015 Nov 17;9:264.

Zorkin, N.G., et al. Severe Hypothyroidism Presenting with Acute Mania and Psychosis: A Case Report and Literature Review. Bipolar Disord. 2017;3(1):1.

Urinary System

Basu, G., Mohapatra, A. Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab. 2012 Mar-Apr;16(2):204-213.

Chang, Y.C., et al. Subclinical and overt hypothyroidism is associated with reduced glomerular filtration rate and proteinuria: a large cross-sectional population study. Sci Rep. 2018 Feb 1;8(1):2031.

Cuevas, E., et al. Moderate-to-high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years. Clinical and Experimental Pharmacology and Physiology. 2017 May;44(Suppl 1).

Cuna, V., et al. Functional Abnormalities and Thyroid Nodules in Patients with End-stage Renal Disease. In Vivo. 2017 Nov-Dec;31(6):1203-1208.

Da Costa, A.B., et al. High prevalence of subclinical hypothyroidism and nodular thyroid disease in patients on hemodialysis. Hemodial Int. 2016 Jan;20(1):31-7.

Garrido-Magaña, E., et al. Thyroid dysfunction in children with chronic renal failure. Nefrologia. 2009 Oct;29(5):502.

Gupta, A., et al. Thyroid dysfunction in patients of chronic kidney disease. Int J Adv Med. 2017 Oct;4(5):1333-1337.

Justo, D., et al. Asymptomatic urinary retention in elderly women upon admission to the Internal Medicine department: A prospective study. Neurourol Urodyn. 2017 Mar;36(3):794-797.

Keller, J.J., et al. Comorbidities of bladder pain syndrome/interstitial cystitis: a population-based study. BJU Int. 2012 Dec;110(11 Pt C):E903-9.

Liakopoulos, V., et al. Acute Renal Failure: A Rare Presentation of Hypothyroidism. Renal Failure. 2009;31(4):323-326.

Mariani, L.H., Berns, J.S. The Renal Manifestations of Thyroid Disease. JASN. 2012 Jan;23(1):22-26.

Moeller, R., et al. Adolescent with Rhabdomyolysis due to Undiagnosed Hypothyroidism. Case Rep Pediatr. 2011;2011:670673.

Mohamedali, M., et al. Thyroid Disorders and Chronic Kidney Disease. Int J Nephrol. 2014;2014:520281.

Pakhle, K., et al. Thyroid dysfunctions in patients with chronic renal failure. Int J Res Med Sci. 2017 Jun;5(6):2773-2778.

Patil, V.P., et al. Evaluation of renal function in subclinical hypothyroidism. J Lab Physicians. 2018 Jan -Mar;10(1):50-55.

Rhee, C.M. The Interaction Between Thyroid and Kidney Disease: An overview of the Evidence. Cure Open Endocrinol Diabetes Obesity. 2016 Oct;23(5):407-415.

Saha, S., et al. A Study on Renal Function Status of Patients with Hypothyroidism attending a Tertiary Care Hospital in North Bengal. Indian Journal of Medical Biochemistry. 2018 Jan-Jun;22(1):10-17.

Stan, M.N., Drake, M.T. Failing Kidneys and Thyroid Dysfunction – An Undesirable Synergy. Mayo Clinic Proceedings. 2018 May;93(5):555-557.

Uemura, O., et al. Influence of thyroid function ion glomerular filtration rate and other estimates of kidney function in two pediatric patients. CEN Case Rep. 2018 Feb 28.

Van De Merwe, J.P. Interstitial cystitis: a review of immunological aspects of the etiology and pathogenesis, with a hypothesis. BJU International. 2000 May;85(8):995-999.

Zabuliene, L., et al. Associations between thyroid and kidney functions. Endocrine Abstracts. 2017;49:EP1276.

Respiratory System

Ali, E.R. Assessment of functional lung impairment in patients with thyroid disorders. The Egyptian Journal of Bronchology. 2016;10(3):337-347.

Al-Sofiani, M., et al. Hypothyroidism and non-cardiogenic pulmonary edema: are we missing something here? Endocrinol Diabetes Metab Case Rep. 2015;2015:150014.

Basoglu, O.K., Tasbakan, M.S. Gender difference in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath. 2017 Feb 14.

Condruta, L., et al. Respiratory manifestations in endocrine diseases. Clujul Med. 2016;89(4):459-463.

El-Shabrawy, M., et al. Treatment outcome and predictors of better response to thyroxin in hypothyroid patients with sleep apnea syndrome in Zagazig University hospital. Egyptian Journal of Chest Diseases and Tuberculosis. 2017 Apr;66(2):285-291.

Fan, Y.M., et al. Prognostic factors for treatment success in patients with multidrug-resistant tuberculosis in China. Int J Tuberc Lung Dis. 2018 Mar 1;22(3):300-305.

Glyn, T., et al. Lessons learnt from a case of missed central hypothyroidism. Endocrinol Diabetes Metab Case Rep. 2017 Dec 2;2017.

Hamdan, A.L., et al. Phonatory symptoms and impact on quality of life in female patients with goiter. Ear Nose Throat J. 2016 Jul;95(7):E5-E10.

Kamaeva, I., Shaporova, N. Possible mechanisms of worsening bronchial asthma coexisting with thyroid gland pathology. European Respiratory Journal. 2013;42(Suppl 57):P585.

Lencu, C., et al. Respiratory manifestations in endocrine diseases. Clujul Med. 2016;89(4):459-463.

Madhuri, G., et al. Evaluation of thyroid dysfunction in chronic obstructive pulmonary disease. Biomedical Research. 2013. 24(1):110-113.

Misiolek, M., et al. Sleep apnea syndrome and snoring in patients with hypothyroidism with relation to overweight. J Physiol Pharmacol. 2007 Mar;58 Supplements 1:77-85.

Munehisa, F., et al. Respiratory failure associated with hypoventilation in a patient with severe hypothyroidism. Respirol Case Rep. 2014 Jun;2(2):79-80.

Nafae, R.M., et al. Thyroid function in respiratory failure patients. Egyptian Journal of Chest Diseases and Tuberculosis. 2014 Apr;63(2):513-521.

Naveen, D., et al. Idiopathic Pulmonary Fibrosis and Hypothyroidism. Cannot Forget Subclinical Disease and Difficult-to-Eliminate Corticosteroids. Chest. 2016 Feb;149(2):600.

Papaioannou, O., et al. Metabolic Disorders in Chronic Lung Diseases. Front Med (Lausanne). 2018 Jan 18;4:246.

Paul, J., Dasgupta, S. Co-morbidities in Hypothyroid Patients in a Tertiary Health Care Hospital in India. Journal of Thyroid Disorders & Therapy. 2012;1:106.

Petrone, A., et al. Abnormal thyroid hormones and non-thyroidal illness syndrome in obstructive sleep apnea, and effects of CPAP treatment. Sleep Med. 2016 Jul;23:21-25.

Sadek, S.H. Pulmonary consequences of hypothyroidism. Ann Thorac Med. 2017 Jul-Sep;12(3):204-208.

Simmons, L.H., et al. Case 38-2014: A man with sore throat, hoarseness, fatigue, and dyspnea. N Engl J Med. 2015 Mar 5;372(10):982.

Sorensen, J.R., et al. Respiratory Manifestations of Hypothyroidism: A Systematic Review. Thyroid. 2016 Nov;26(11):1519-1527.

Ulasli, S.S., et al. Effect of thyroid function on COPD exacerbation frequency: a preliminary study. Multidiscip Respir Med. 2017 Dec 14;14(12). pii: E1576.

Valjevac, S., et al. Assessment of Lung Dysfunction with Spirometry in Patients with Thyroid Disorders. Acta Inform Med. 2011;19(1):16-18.

Cardiovascular System

Altamirano Ufion, A., et al. Subclinical Hypothyoridism and Its Association with Increased Cardiovascular Mortality. Cardiol Res Pract. 22017;2017:7539735.

Bano, A., et al. Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study. Circ Res. 2017 Dec 8;121(12):1392-1400.

Beukhof, C.M., et al. Effects of Thyrotropin on Peripheral Thyroid Hormone Metabolism and Serum Lipids. Thyroid. 2018 Feb;28(2):168-174.

Binu, A.J., et al. The Heart of the Matter: Cardiac Manifestations of Endocrine Diseases. Indian J Endocrine Metab. 2017 Nov-Dec;21(6):919-925.

Charles, L., et al. Secondary Hypertension: Discovering the Underlying Cause. Am Fam Physician. 2017 Oct 1;96(7):453-461.

Evagelopoulos, M.E., et al. Mitral valve prolapse in young healthy individuals. An early index of autoimmunity? Lupus. 2009;18(5):436-440.

Floriani, C., et al. Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update. Our Heart J. 2018 Feb 14;39(7):503-507.

Funasako, M., et al. Hypothyroidism Frequently Occurs in Pulmonary Arterial Hypertension Associated with Connective Tissue Disease Compared with Idiopathic and Hereditary Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2012. 135:A1906.

Grais, I.M., Sowers, J.R. Thyroid and the Heart. Am J Med. 2014 Aug;127(8):691-698.

Iaccarino, G., et al. Thyroid function predicts increased cardiovascular risk. Int J Cardiol. 2018 Mar 1;254:338-339.

Iijima, T., et al. Concurrent variant type 3 autoimmune polyglandular syndrome and pulmonary arterial hypertension in a Japanese woman. Endocr J. 2018 Feb 16.

Ionescu, S.D., et al. Massive pericardial effusion associated with hypothyroidism. Rev Med Chir Soc Med Nat Iasi. 2014 Jan-Mar;118(1):87-91.

Lei, L., Mao, Y. Hormone treatments in congestive heart failure. J Int Med Res. 2018 Jan 1:300060518761262.

Leonardi, A., et al. Pericardial Effusion as a Presenting Symptom of Hashimoto Thyroiditis: A Case Report. Int J Environ Res Public Health. 2017 Dec 14;14(12).pii.

Lim, H.J., et al. The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans. J Korean Med Sci. 2017 Oct;32(10):1626-1632

Mourtzinis, G., et al. Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control study. Our J Prev Cardiol. 2018 Jan 1:2047487318759853.

Ning, Y., et al. What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants. BMC Medicine. 2017;15:21.

Parent, S., Cujec, B. Subclinical Hypothyroidism and Heart Failure: Chicken or Egg? Can J Cardiol. 2018 Jan;34(1):11-12.

Patel, D.K., Gujral, J.S. Atrial Fibrillation in Hypothyroidism. JIACM. 2009;10(3):140-142.

Rizzo, C., et al. Dysthyroidism and Chronic Heart Failure: Pathophysiological Mechanisms and Therapeutic Approaches. Adv Exp Med Biol. 2017 Dec 13.

Sarfo-Kantanka, O., et al. The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana. J Diabetes Res. 2018 Feb 1;2018:4783093.

Shende, P., et al. A Study of Cardiovascular Changes in Newly Detected Hypothyroid Patients. MVP Journal of Medical Sciences. 2017 Jul-Dec;4(2):102-106.

Udovcic, M., et al. Hypothyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017 Apr-Jun;13(2):55-59.

Yadav, Y., et al. Cardiovascular Risk Factors in Children and Adolescents with Subclinical Hypothyroidism. Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):823-829.

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About Dana Trentini

Dana Trentini founded Hypothyroid Mom October 2012 in memory of the unborn baby she lost to hypothyroidism. This is for informational purposes only and should not be considered a substitute for consulting your physician regarding medical advice pertaining to your health. Hypothyroid Mom includes affiliate links including the Amazon Services LLC Associates Program.

Comments

  1. Rosetta Hicks says

    I have it also and i m tired all the time it’s making me sick even with my other medical issues i m going through so i really do not know which one is affecting my body most of the above i have now it’s hard sometimes when i go to my doctor it seems like my illness is affecting my whole body cause i don’t know really on which one is affecting me more.ok that’s ot for now.

  2. Wow. 106. I was already diagnosed with hypothyroidism about 2 years ago now, but going through this list was eye opening as I had no clue that all these things I deal with are linked to the thyroid disease. No clue at all.

  3. Julie Christine Forrest says

    The journey begins today!

  4. My doctor seriously just said to me “you have some problems with your thyroid, so you need to take Levaxin (the Swedish meds). It very common with pregnancy and usually it passes after delivery”. That was 2 years ago, and this last year they haven’t been able to get the dose right one single time. They still haven’t said anything about it being a disease or anything. It was when I went to my dentist a couple of weeks ago that I realized I’m actually sick. I had to fill a form with random questions like “do you have any health conditions” and “are you on any medications?”
    I answered no on the first one, and yes on the second one, and my dentist just said “oh, so then you have a thyroid disease?” And I was like “no…? I just take one pill!” And she said “well, if you take that medication then you have a thyroid disease!”

    I never even thought of that! I got no information from my doctor, and now, after doing some
    Research, I’ve realized that this is probably the reason why I’ve felt so horrible these last two years. Depression, anxiety, tremor, heat and cold sensitive, sleep issues, digestive issues and so on… I’ve been to my doctor with all of these problems but NOT ONCE have they told me it can have something to do with my thyroid.

  5. Thank you for putting this list together- I wondered if you have come across twitching related to Hypothyroid? Facial twitching of eyelid and above lip or head twitch? Thanks!

    • Connie Davis says

      I’ve had chronic eye twitching for decades & have been diagnosed with Hashimoto’s Thyroiditis. It was on the list.

    • BobbiiBlue says

      Hello Mary,
      I saw “twitching of eyelid” listed as a symptom under heading “ Eyes & Hypothyroidism.” It’s easy to miss with all the symptoms. Stay healthy & well and God Bless.

  6. After 3 or 4 doctors told me my thyroid was normal, an endocrinologist finally saw that it wasn’t. I have been on levothyroxine for about 6 months. I have no idea if I feel better. A few months after that he diagnosed me with premenopause. I was a mess: screaming and crying over little things and felt like I was in an oven all day. He put me on HRT. Now the issue is I am extremely lightheaded, dizzy, balance is horrible, have fallen over a few times, doing and saying things that I don’t remember doing as if I’m blacking out, doing things that don’t make sense, etc. I am so scared/miserable. I read side effects of levothyroxine and all these symptoms are on it. So I thought I should stop taking the levothyroxine. I’m down to a quarter of 0.025mg and I have felt even more horrible the past 2 days. So what if it’s the HRT and not the levothyroxine?? I have no idea what to do and no doctors seem to know what’s going on, even the endocrinologist.

    • Connie Davis says

      RESEARCH! Get copies of your test results. Look up each result individually to see what they are for, what normal is and what high & low means to your body. Then…find another dr that will listen to you. It took my late husband dying of a brain bleed for me to realize that I had to become the dr & know what was the right & true treatment for him (unfortunately, too late for him). If something doesnt seem right or I dont FEEL right, I will gladly go until I get the answer that makes sense for MY body. Had a dr told me once in the 80’s that “know one should know your body like you.” Get your head out of the sand & start listening to what it tells you. Ive worked around drs all my life – they are only humans & dont have time to research about your condition like YOU do as many times they have patient loads of over 3000. Take responsibility for your care into your hands where it belongs. Speak up for you – as they make mistakes. And remember that they can only treat you based off the HISTORY of what you give them. Better the history – the better your treatment. EVERYTHING is important. Take notes with you so its in order & to ASK QUESTIONS. This is what I’ve found in my 40+ yrs in getting the kind of treatments I need. I had 67 of the symptoms listed.

      • BobbiiBlue says

        Connie,
        I’m sorry for the loss of your husband. That is a difficult way to become knowledgeable, but I am glad you are now.
        I am a Registered Nurse & I would like to commend you on your excellent advice!
        I believe that a patient is always right, even when the aren’t! If a patient questions me about something or feels something isn’t quite right with their treatment, I stop what I’m doing & go back & check orders and follow up.
        I try to teach my patients to always listen to their bodies. No one knows you body like you do!
        I encourage them to take a list of their symptoms into their appointment & ask questions. “Don’t be afraid to take notes & keep records. Try to research & learn about what you can because knowledge empowers you. Most importantly, find a Dr who you are comfortable with & who works for you.”
        Older people are easily intimidated by the Dr or they tend to still think that a Dr’s word is like God’s word, but I remind them Dr’s are only human as you stated. Thank you for sharing your knowledge & I hope many people read your post & learn!
        Stay safe & healthy & God Bless you & your loved ones.

  7. Jerry Atson says

    My father was diagnosed with ALS in the summer of 2013;  His initial symptoms were quite noticeable. He first experienced weakness in his right arm and his speech and swallowing abilities were profoundly affected. We all did our best to seek help for this disease no medications they prescribe worked ,we were all scared we might lost him due to his condition, as he had been his brother’s caregiver a few years earlier for the same disease before he past. doctor recommend nuatural treatment from total cure herbal foundation for his ALS we have no choice to give a try on natural organic treatment ,this herbal cure has effectively reverse my father condition ,losing his balance which led to stumbling and falling stop  after the completing the herbal supplement which include his weakness in his right arm and his speech, home remedies from totalcureherbsfoundation.com is the best although their service is a little bit expensive but it worth it, they save lives.

    • Connie Davis says

      AWESOME! Everyone is different & what works for one, doesnt work for another. My hsbnd had horrible kidney stones & 3 lithotrypsies with no real results. ER dr told him his kidnsey looked like “a gravel pit.” They wanted to send him to have a surgery that would basically leave a stent “open out of his back that they could just drain them through.” He found a supplement “Renavive” that he started taking over 6 yrs ago. Had an ultrasound and they found NOTHING there! But our dr STILL declines to believe that it has anything to do with this herbal supplement. I say, “Whatever works!” Best wishes to your father!

  8. Brenda Heeligan says

    Re: Brenda Heeligan’s comments, I forgot to say the dosage I was posting about was for my Levothyroxine. Just typing this is so tiring. Many thanks.

  9. Brenda Heeligan says

    This article has been eye opening to me, I have so many of the conditions you have mentioned. I’m so thankful I found your site. I now realise hypothyroidism affects so many parts of the body. The fatigue is so debilitating that you feel your life is ebbing away and no way of getting it back on track. I’ve lived with this for so long I just wish there was something more that I could do to help myself. I’ve been taking selenium for over three months my doctor has also put me on a high dose of vitamin D. Needless to say nothing seems to be working, I’m on 100mcgs one day the next 50, then 75, I must admit to getting the doses mixed up occasionally even with a chart. My eyesight is now deteriorating. Once again thank you for enlightening me with your research. Brenda.

  10. Patrick power says

    long time reader 2nd time message. being a male 52 considered to be in good health after reviewing the list I have at least 100+ symptoms. Have had problems with thyroid probably since 2011 or 2012 took me till 2017 to get diagnosed with hypothyroidism. my doctor then put me on the levothyroxine and started me out at 0.5mg and after about a year it leveled off and they took me off the medication at that time I was making decent progress and felt pretty good but then after being discontinued I had went and seen endocrinologist and upon reviewing my records and he to made a diagnosis of fibromyalgia. went back to my primary have a new relationship with a new doctor who happens to be female and has really good insight thank god. But the most pronounced pain & symptoms I seem to have as of late or intense shoulder& neck kind of like skull pain ear and eye pain that results in dizziness and vertigo I’ve been on a ton of meds trying to stay clear of opioids, Tramadol seems to help what else can I do to subside these dizzy spells with all this so it sounds funny but hallucinations when I lay down and sleep. If I am able to sleep and I understand that rest is huge in combating these symptoms. I’ve recently talked to several people that encouraged me to go and start using the CBD oils which are broad-spectrum but extremely low THC. Having a squirrel moment and regressing back to my latest score was at 3. and then went up 5 the doctors still seemed skeptical and say it’s only a couple points started me on .25mg it’s not working as I remember before living in Az we are limited to good Dr.what words of wisdom can you share for a direction of treatment.

  11. It’s sad when you tell multiple doctors that when your old doctor let you try the thyroid meds, you felt soooooo much better and your POTS went into remission for 10 years, but is now back, and they still REFUSE to even try you on a small dose!😓

  12. Does anyone have any problems with there eyes like you watch your scrolling on the phone or tv/ computer
    I also have trouble going into the store to look for things I need idk if it is a sensory overload or what
    Eye pain around orbital sinus since last June
    I have had hypo for 10 years and diagnosed with hashimotos in February of this year
    Previously on levothyroxine
    I’m on tirosint now but still having problems
    I feel like my left eye swells around it and experience nerve sensations

    • Patrick power says

      Yes had Hypothyroidism for almost 9 years went through 3 doctors. one who removed me from my meds unwillingly of course,but during the year brake off of the meds I have those issues. do you by chance have light sensitivity I’m back on meds I use systane gel drops helps alot and believe it or not CBD oil helps with a lot of side effects on the list.

  13. I suffer from very high anxiety, nervousness and hand tremors. These are supposed to be symptoms of hyper in stead of hypo but all my blood tests show I am hypo. On Levo right now and hopefully it’s the right thing. But can hypo symptoms imitate hyper?

  14. Patricia says

    Don’t give up. Do your own research but use books as well as the internet. There is a lot of information but you have to check the sources to make sure is accurate and updated.
    It is difficult to get the right dosis at first so you must insist on retesting. Not all of the symptoms go away but most do improve. The key is to learn and speak up with your Dr. To get the correct dosis and combination of T3 and T4 Medicine . Read about it till you understand. And Anita you must get help. There must be a low income clinic where you can get help. Best wishes to all. It does get better once you get the right dosis.

  15. Lori McKinney says

    I had 114/306 . Probably more because alot of them I didn’t know what they were. Like the diseases. I have compared my symptoms with Hashimoto’s disease and it nailed my symptoms. I have not gone to Dr due to money n no Insurance. Government health insurance is a scam also. I can’t afford. I have had one panel of blood tests thru the county health Dept but I did not fast before test. They didn’t tell me. Now I am worried. They told me to go to a primary care Dr. If I could afford to I would. I am 54 n barely survive on what I make a week. Any suggestions?

  16. Look up Dr Levy on YouTube and learn about high dose vitamin c and magnesium. I have had a lot of issues with my thyroid and drs that just don’t get it. Look it up and let me know.

  17. Anita Markwick says

    Hi. I am desperate for help. I have 95 of the symptoms listed and my Dr says I am borderline hypothyroid and won’t treat me until I slip over the magic line. My quality of life is zero, sleep all the time, stumbling and falling over when I get up. I can’t get out of the house as I have tremors and vertigo, I can’t trust myself to drive.
    Does anybody have any suggestions as to how I can get treatment please? I am 59 and feel as though my life is over. I have recovered from breast cancer last year and I want to be making the most of my life, bit instead feel almost housebound. I also have diabetes type 2, diagnosed 2 months before breast cancer. I am just not coping, please help.

    • mari hyland says

      Anita, Look for another doctor. There is someone out there who is holistically minded who will treat you. Do a search on the internet for your area. Perhaps a DO — a Doctor of Osteopathy — because they are more holistic than MDs. Or find some a nutritionist. You can get better thru nutrition. MDs are extremely controlled as to what they can and cannot do by the AMA. As far as I’m concerned the medical world is at least 40 years behind the nutrition world.

      • mari hyland says

        Anita, Look for another doctor. There is someone out there who is holistically minded who will treat you. Do a search on the internet for your area. Perhaps a DO — a Doctor of Osteopathy — because they are more holistic than MDs. Or find a nutritionist, or a Doctor of Oriental Medicine. You can get better thru nutrition. MDs are extremely controlled as to what they can and cannot do by the AMA. As far as I’m concerned the medical world is at least 40 years behind the nutrition world.

  18. Same here. My hypothyroidism has led to alopecia areata, my hair is thinning a LOT and I’m losing small handfuls from light brushing on a daily basis. My dermatologist has been trrating my alopecia with cortisone scalp injections for the past 3 years with success up until now. I have new patches sprouting in the back of my head and a bald spot that refuses to regrow hair after countless injections to the same spot….I was prescribed naturethroid 32.5mg but no relief from alopecia, excruciatingly painful intense foot, toe, calf muscle, inner thigh muscle cramps (lasts for 10-20mins), ankles swell, my toes and fingers,are always freezing cold; my energy levels and attention span and memory are all affected in a negative way….and I cannot lose weight like I used to when I was younger….
    I’m 38 years old, no family history of alopecia areata or hypothyroidism…i just don’t understand why this happened to me, how this manifested/what triggered it.

    • My OBGYN is who listened to me and run test. He started treating me! Keep searching for a doc. Who will listen to you! It took me years to find one.

    • Cramps are frequently a result of too little magnesium or potassium or both. I use Ancient Minerals topical oil for best absorption of magnesium. Try banana or figs for extra porassium. I eat these prior to exercise, no more calf cramps.

  19. What can you do? All my Dr. Does is put me on a thyroid pill. I still have all the symptoms.

  20. Cheryl Carr says

    What difference does it make if you have a ton of these symptoms that point to thyroid problems? Your doctor will do that simple, but stupid, inconclusive thyroid test and tell you that you don’t have a thyroid problem! Why won’t doctors do a more complete test to determine if you do, in fact, have a thyroid problem?

    • Connie Davis says

      Ask them to do a thyroid antibody test. If its high, this points to Hashimoto’s Thryoiditis. He cant ignore it then. Is there a family history of thyroid issues? HISTORY is very important in getting a good diagnosis. Go prepared when you see your doctor. Take a list of questions. Ive worked with drs my whole life. They are given 15 to 30 mins with you & are expected to keep that schedule. If you come with a list of questions for them to address, this makes good use of their time & yours. Also, be aware that they generally have a patient load of about 2000 patients & cant possibly research your medical issues like you can. Getting a dr to LISTEN to you is for them to KNOW that your not a hypochondriac but someone that has RESEARCHED their issues. I actually had my dr tell me NEVER to go to WebMD but if I wanted to research, to go to the Mayo Clinic website. Also, get copies of your lab tests or xray results & look up each one individually to find out 1) what they are for 2) what they do 3) what the difference in a high or low reading effects your body. I’ve even looked up each word to get an understanding of what they mean. This is time consuming but it helps you to understand everything so that when you go to your dr, he knows you are not a “YouTuber” but have a basica knowledge of what youre talking about. He will take you seriously. If not…LEAVE & go to someone who will. My late hsb died of a brain bleed because I didnt realize I had to be the brain surgeon. Dr’s dont know everything & make mistakes. My care is my responsibility. 🙂

  21. Wendy Lambing says

    I’m 45 and have been diagnosed with hypothyroidism. .I was immediately put on levothyroxine and all I did was gain weight so I switched from a nurse practioner to an actual medical doctor and she put me on Armour Thyroid! And yet again all I continue to do is GAIN ..I’m so fed up I want answers ..

  22. I work in the medical community as a physician. I find it very difficult to obtain answers to many of the symptoms posted. About 15 years ago, I had my endocronologist diagnose and surgically remove a 10 cm. tumour. In the past year, a CT scan revealed that I now have four small tumours (about 1 cm. each). He is unsure about treatment. What would you recommend. Thank you.

  23. Thank you so much for posting all of the symptoms! I will say, a LOT of them are exactly the same as having Ehlers-Danlos Syndrome (the hypermobility type), psoriatic arthritis and small fiber neuropathy. EDS is a soft tissue disorder that is cellular-the cells make weak, faulty collagen that doesn’t hold any body part together well. The elastin production is fine…stretchy skin that is porceline smooth, 1 that overstretch and sometimes break, joints that hyperextend causing all of the muscles to take all the support since the joints bend and lock slightly (or severely) backward. I’ll be asking about my thyroid at my next rheumatologist appointment because I have most of the 300 listed symptoms. If anyone else has similar symptoms, have a look at EDS and the Beighton Scale.

  24. Jessica Chauvin says

    Drs. Are refusing to diagnose us bc it keeps them in business with all of the ailments and conditions that come along with this disease. . I know I have hypothyroidism. Question is, how do we treat ourselves in order to lessen the symptoms before we die of some complication stemming from it?

    • Alice DaleThomason says

      On this site there are many suggestions. I know I have started with diet and researching as much as I can for a better doc through my insurance list and specifically at a teaching Hospital! Good Luck!

    • Debbie Podesta says

      I see a naturopathic doctor that specializes in thyroid issues. She is willing to work with me on trying different things and supplements to ease a lot of the symptoms.

  25. What do they do if you have thyroidism what’s the course of action. How do they treat it

  26. I have had symptoms for years. Of my 9 siblings 6 of the girls have bad thyroid problems 1 of the boys. I also have s lot of nieces that have bad thyroid problems, as did my mother. One sister has graves disease. I have be ed n checked by a regular doctor and told I was fine every time. Now they just tell me it’s my age, I hate that. How di I look for a doctor that will treat my symptoms. Almost 100.

  27. At what score should I be concerned?
    I can’t find that in t article.

  28. Robert Brown says

    Ms Trentini, please publish all the studies if you can for every symptom in the article
    Thank you all your hard work and research.
    Robert Brown

  29. Amanda Cheatham says

    I have to have an ultrasound done on my thyroid Monday… dr said my blood work shows my level is 320… I just had a miscarriage about 2 weeks ago I was almost 6 weeks along. After the miscarriage is when they did all this blood work but I have a lot of these symptoms and have for years. I use to workout 5-6 days a week for almost a year along with diet and only lost like 10 pounds. Hoping to get some answers and get started on a treatment seeing as I believe I have hypothyroidism.

    • I’m so sorry to hear of your miscarriage. I learned I had it after my period had stopped. I went for bloodwork to check if I was expecting, and that’s when the doctor told me.

  30. I have to have an ultrasound done on my thyroid Monday… dr said my blood work shows my level is 320… I just had a miscarriage about 2 weeks ago I was almost 6 weeks along. After the miscarriage is when they did all this blood work but I have a lot of these symptoms and have for years. I use to workout 5-6 days a week for almost a year along with diet and only lost like 10 pounds. Hoping to get some answers and get started on a treatment seeing as I believe I have hypothyroidism.

  31. Lisa Williams says

    My total of symptoms is 146. I am 55 years of age and was diagnosed with hypothyroidism 6 years ago, my other diagnosis – depression, essential primary hypertension, Chronic Fatigue Syndrome with Fibromyalgia, Hypothyroidism, Eczema, Hyperlipidemia, Elevated liver enzymes, OSA on CPAP, Perimenopause, Irregular menstrual bleeding, Autoimmune disease.
    I take the thyroid medication Tirosint 75 mg since February 2018. I did not think all of my symptoms was thyroid, seems my hypothyroid is causing all these issues until as reading all the listings on this website.
    I fired my old endocrinologist and rheumatologist. I hope that my new endo will work with me to help get more options to try and get my symptoms to a mangle place. I am going through menopause. My diagnosis’s and the medication treatment often have side effects of the vicious chronic fatigue. I cannot tell you how much this website has helped me. Thank you so very much. Lisa

  32. Lisa Williams says

    Thank you so very much for this web site. It has truly given me hope that I have not had in 8 years. Every article, every symptom all this information has allowed me to now the ability to recover and heal. Sincerely. Lisa

  33. Robert Brown says

    Hi I just came back from my diabetic eye exam (includes Glaucoma also) My pressure reading were 15 + 5 and 13+5 or 20 right eye and 18 in left. Last year when my doctor had raised my desiccated thyroid from 2 grains gradually to 4.5 grains they were 10 and 7 respectively. I made a statement that I thought the desiccated thyroid had made a difference. My Ophthalmologist didn’t like the statement . He said what makes you that,
    I referred that I had found on the internet the study published about open angle glaucoma on your 300 Hypothyroid Article ( case studies). and tried get me to believe it was bogus. Which I don’t believe it is bogus. Doctors continue to allow patient to suffer
    in pain while continue to get paid. During the increase in desiccated thyroid I lost 40 lbs in
    ten months . The weight is back on now a year later.

    Robert Brown

    • Sharon La Croix says

      You got one more follower towards your 750 million. Just found you when I googled the proper storage of thyroid medication. Can”t remember if that was your article, or if the article then led me to you. However, I am here now and anxious to read everything you have written.

  34. Thank you for this list – it is extremely insightful. Your work is much appreciated.

    Is there any way to print this article with all of the informational bullet points but none of the graphic images? (faces/images behind the words make it difficult to print and read)

  35. Victoria Ward says

    Awesome List,. I have more than half of All AND This is not a disease but a CURSE!!

  36. Diane Craddock says

    I was diagnosed with hypothyroidism in my middle to late 30’s. I am now 71. I have always been prescribed Synthroid, now Levothyroxine due to cost I guess, and the only changes over the years have been the strength of the dosage in the range of 90-110; most often 100mg. To my knowledge I have had only the TSH blood test which from reading your information is the T4. Blood tests have indicated my thyroid condition is being managed properly. However, I still have many of the symptoms listed. When first diagnosed, my doctor said I’d be dropping the pounds as soon as the medication was in my system – never dropped a pound. I used to be thin in my teens and early twenties and would eat high calorie foods in an attempt to gain weight. That all started changing in my late twenties – pound by pound. Is it possible the other T levels and the TPOs and TgAb are out of sync? I have my first appointment with a new doctor, and since being on Medicare, in 4 days. I am going to eMail her through the patient portal with the request for more thorough blood testing re my hypothyroidism. I’m very curious what her response will be.

  37. Teresa A Wenner says

    103

  38. I’m just now finding your artical. I will be ordering the book!

    Looking back, I believe I have had symptoms all my life but it wasn’t until my late 20s that I started putting 2&2 together. I have yet to find a doctor to take me seriously and others only test my TSH just to get me out of their office. Of course it is ‘in normal range’. (1.4-1.95). I would go every few years when my symptoms would get bad. Hitting the brick wall as I call it.

    I (finally) have an appointment next Friday with a highly published encronologist. I say finally because all the encronologist in my area want a referral from primary doc before they let you make an appointment. I hope he takes me seriously and does every test in the book! Take all my blood! The way I feel every day, I won’t feel any worst! 🙂

    My score is 146+. Plus meaning I haven’t researched those items but the little I know of them, it could be possible.

    Thank you for all your hard work; typos and all! 😉

  39. I’ve been asking for over a yr why my toenails ( not fingernails) r not growing n r splitting n peeling. Wt gain – workout x3/7, n my hair has stopped growing… hmm maybe u banged your nail bed on toes ( ok but for a yr?) I’ve been u set extreme ant of stress x16 mos, but still try to workout n eT healthy-yet I’m told my throws is fine… ty I’ll be showing this to my new doc in hopes we can get on bd with this🙂

  40. I highlighted entire pages from this list and again was told that my thyroid was fine. At least my NP put me on progesterone. I really don’t know what to do anymore and I’m so tired of treating so many phantom illnesses; gluten sensitivity, itchy hands and feet (oh, that’s just “seasonal allergies”) the scaly skin building up on my feet, the brain fog making my job so difficult. Is it more likely I’m suffering from several different conditions, or that a dysfunctional thyroid is causing so many cascading problems?

  41. Denise Perry says

    Thank you for this list!!! I will be 60 next year and after years of being diagnosed with this or that and no one willing to tie them together, your site has been the most beneficial to me. The last 8 years I had an elder doctor who would not do detailed thyroid tests. Now I have a new doctor – one who listens!!! Before blood tests results are even back, she has placed me on Armour – she said my years of symptoms and health events speak loudly! She is aware of false negatives on testing as well. What a breath of fresh air it is to have someone really listen! I had been noticing longitudinal ridges on my nails and that my half moons have all but disappeared and I see from an earlier article that is a symptom. My journey began with body wide pain and stiffness when I was quite young. Oh you have Chronic Pain Syndrome. Then came IBS (and a host of other digestive issues), gluten intolerance, a molar pregnancy, advanced endometriosis, glaucoma, gallstones, restless leg syndrome, over senstitive hearing, sporatic itching, internal shivering, low libido, loss of ends of eyebrows, poor night vision, weight gain and inability to lose it, tendency to stay cold, tiny bumps mostly on legs), diverticulosis, acid reflux, burping / trapped air (regardless of what I eat), chest pain (began before puberty), fatigue, low body temp and many more things. Many happened gradually over the years so it was not until I saw the list the first time you threw out there, that I began to make connections. I also have swollen places at the base of my neck toward the shoulder. Sometimes they are bigger and turn a pale yellow or blue. The old doc had a sonogram done at my insistence and found nothing and said he had seen these many times before and they were normal. New doc takes one look and says – no, that is endocrinal. The most beautiful words the new doctor said to me? “We will dig and dig until we get answers.” This happened this past Monday and I am awaiting my prescription with much anticipation. If it works, I cannot even fathom feeling different than I have for most of my life. What an exciting prospect. I will continue to read your updates and educate myself. Many thanks for your continued efforts!

  42. Judy L Matrundola says

    I gained 15 pounds due to my Hypothyroidism. About 5 years ago, I started taking Raw Fit to help me lose weight, and it really worked well. However, now I take it every day for lunch, but it is not working now due to the fact that I am still gaining weight and my belly is increasing. I would like to know how I can actually lose weight.

  43. Starr D. says

    Thanks very much for putting “Non Alcoholic Fatty Liver Disease” at the top of
    your liver & gallbladder section. I had to work real hard to find any research
    linking these conditions about three years ago, when my brother was diagnosed
    with NAFLD, but I was pretty sure he’d been hypothyroid for a LONG time
    before, but undiagnosed. Found a smarter endo to give my brother extra
    thyroid labs (like for antibodies), and he did show up as having Hashi’s.
    and he was put on synthetic thyroid meds…..first generic Synthroid, then
    added generic Cytomel to that.

    I don’t think my brother is doing as well as he should be, though, because
    these meds don’t seem to be getting in & doing enough for him. I’m trying
    to convince my brother to ask the doctor about trying a little natural thyroid
    medicine to see if that would help better. I have a theory that it might
    work better, as I’ve noticed the natural thyroid meds seem to help me better
    more complicated issues (like excessive bleeding from periods that I had, and
    wounds that weren’t healing.) Thanks for all your research, and one question:

    Did you find anything saying that patients with Non Alcoholic Fatty Liver
    Disease do better with at least some natural thyroid hormone in the mix, rather than just synthetic? Just wondering…..I will still be researching, too! Starr D.

  44. Ms. Dana

    Thank you so much for the information you have compiled in this and other articles. I am a 45 year old female. I have had type 1 diabetes since age 4 and Multiple Sclerosis since age 34. My THS levels are always checked, as diabetics are no stranger to Thyroid Disease. In fact, autoimmune diseases run in twos and threes. I have many of the symptoms listed, however they are attributed to Multiple Sclerosis and diabetes. Perhaps some of your readers are not feeling better bc they have a coexisting autoimmune disease that has yet to be medically addressed.

    I am waiting on test results now to see why my THS levels are so low. I did learn this and wanted to share. Biotin can give false readings on many blood work test, including thyroid. So here we are taking biotin for hair and nails (high potency biotin was prescribed to me for MS) and we get tested only to get false thyroid tests. I’ve done much research and mis medicating individuals for thyroid conditions that aren’t there is a real problem.

    I just wanted to add this, as someone who may or may not have Hoshimotos. I JUST found out biotin May be the culprit. (I pray this is the case)

    Bc biotin is water soluble, it clears the system in 24-48 hours. I’ve read to stop taking it 4-5 days before bloodworj or other thyroid tests. I was misdiagnosed and mis medicated regarding my MS for 6 years. I just kept getting sicker. I was bed bound for the most part. I’d hate for someone to be misdiagnosed with thyroid disease if it is the biotin causing invalid results.

    I just wanted to share. I will be back to puruse your site as it is very helpful. Best of luck to everyone dealing with any diseases!

  45. Dear Dana
    I have a relitive that has been told by he GP here in the U.K. that she has to wait for her thyroid to burn out before they will do anything for her. She like me has Hashimoto’s Hypothyroidism and is increasingly getting worse. I am very concerned for her. Could you please list for me why it would be better for her not to wait for her thyroid to burn out? I have googled the question, but not had much luck. I am thinking of going with her if I can get her to her GP, or do you think we should see another GP in her practise. She is not on any medication for Hashimoto’s and I think she should be and should be referred to an endocrinologist, but I think this is going to incredibly difficult to get done!
    Kind regards Brigette

    • yup also in the uk, my doc got fed up listening to the symptoms I was reeling off, so after a 4 min consult, wrote down a herb to take ‘black kabosh’- he didnt prescribe it, just wrote it down and sent me on my way. I have 175 in that list with 3 sections totally unanswered because I really don’t know the answers as yet. I do thank Dana for the effort and care to make such a list, its made me realise I need to change docs quickly, or Im gonna expire. My hallelujah moment is my LS is Auto Immune…wow!

  46. Dana, let me tell you how much I appreciate all of your articles and the hard research you’ve done to inform us about these diseases. I only have 76 of these symptoms and most of them were the brain issues. I recently retired, and had planned on finding a part time job, but I can’t remember anything, I’m unteachable, I can’t retain anything, I’m tired all the time, so why look for work??
    I just read an article for The spouse. Great article, I had my husband read it. His first comment was “I had no idea!” He had gotten on me one day cuz the floor needed sweeping, things around the house weren’t done. I’ve been telling him I’m tired all the time and I do what I can. Well, that article made all the difference, and he apologized to me! I’m pretty sure it was on your page. I’m just now seeing a endo, I was just going to my pcp. The first thing the Endo told me was “You’re dose is way too high!” (Armour Thyroid 120mg). So I’m hoping this Dr will help me get better. Now that I’ve written a novel, I just want to thank you for all the information you post, and I don’t care about what font or spelling, keep it up!!

  47. Are there any outstanding thyroid doctors on-line for a face-to-face appointment?

  48. I have over 100 symptoms. Yet, my thyroid is fine! I have several nodules, which have been biopsied at scar tissue. I am on two different thyroid meds, yet I continue to suffer. They say I have Hashimoto’s but don’t know why…. I have a PCP Internist, Rheumy, Endo, Pulmonologist, and none of them are working with each other. Take this pill and see you in six months….

  49. Many thanks for this Dana i was amazed to find i scored 92 and I am one of those people who have been told for years there was nothing wrong with my thyroid..its a shame that few doctors actually look at the patient in front of them any more!. You asked about spelling mistakes, under Energy & lack of sleep: “Lack of concentratioM”
    and under Heart: “HighT or low blood pressure”. Hope thats of help. Thanks again.

  50. Dana
    Very impressed with all the recent research papers that you have provided! My profs of yesteryear would applaud you!
    Thanks for all you share with us.
    Hugs!

  51. Just had thyroid retested today, last time the doctor told me I was both hypo and hypothyroid! What the heck does that mean?. I have 101 of the 310 symptoms. May I ask what Graves and Hiroshimito is and what is the difference? I have gained over 35 pounds in the last 5 yrs, I am really getting scared. Thanks so much for all your info and the list is way more important than the spelling or font! Thank you.

    • Meant to say hyper a d hypothyroid! Tests came back ok, so keep up with synthroid! Still confused, why do tired and gaining weight?

  52. Kristina says

    Thank you so much for sharing all your hard work And dedication with others.
    I am 32 and have struggled with hypothyroidism since 20 I have tried so hard to get help from many different doctors and just barely getting by day to day through the years i hate it. I scored 157 out of the 310. I am currently on 275mcg of levrothyroxine I’ve lost more than 1/2 of my hair feel tired run down sluggish daily pale dark circles Achey soar swelling I mean I am a mess and doctors don’t help thank you for all your help I’m going to push even harder now with doctors now that I have all this wonderful info!

  53. Doreen Hrycun says

    Thanks for all this great information!
    One of my major concerns is my head sweats most of the time. I’m always so conscience and embarrased by my dripping wet hair. What causes this? The rest of my body is fine, it’s just my hair root to tip. Help!

    • Kristina says

      OMG this happens to me as well! Specially in line at the store when checking out then I get anxious and embarrassed people probably think I’m sick or something because it’s definitely noticable

      • Omg me too! I’m so embarrassed at the store!!!

        • Low vitamin D causes head sweating and it’s very common to be low on vitamin D with thyroid issues! So many vitamin deficiencies doctors do not test without you asking… ridiculous really!

  54. your work is much appreciated. I have 14 of the Symptoms on the list and Doctors are not very help full Just put you on the regualr Meds and thinking thats all, but it is not. I had a chat with my Doctor in Germany and she was very concerned about that , on Top of my Thyroid problems I was bitten by a Tick last Summer and I was given a round of Antibiotics. My Doctor in Germany mention ,it could be very well that I have some form of Tick born Disease , which can mimic also up to 300 differnt symptoms of diseases . But I will return in a couple weeks back to my Home Country and will get the Help I need

  55. Hi Dana, appreciate all the hard work. I have 120 of the symptoms on this list, I am on thyroid meds but I believe I need a higher dose, I think I will change doctors. Thanks again!

  56. I just went through the article again Kim and made changes. Should you find any other typos or errors let me know. This took me over 15 hours to get together. I knew it would take considerable time to create but I really had no idea just how much.

    • Thank you for all the work you have put into this subject!

      • Personally I think I have had this problem all my life. Now that I look back on it there wasn’t one doctor that cared enough to fill me in on what was happening to me throughout my life as far as thyroid problems go. When I was a child my mother was told to give me an aspirin by “the doctor”.

        • Get this – When I talked to my doctor about feeling like crap he asked me if anyone in my family had thyroid problems. I told him my mother had this. You know, “Family History” of the problem. He totally ignored what I had told him and went on to tell me that “I don’t have anything wrong with my thyroid”. I got rid of him!

  57. I’m really glad to have found your page and this article. Thank you for the hard work you’ve put in to this article. Two things: first, I am swinging between Grave’s and Hashimoto’s. Hyperthyroid has been mostly what I have dealt with, though I am currently hypo. Is there a list anywhere like this for Grave’s? Second, it is very difficult to read many of the lists with the color of font over a busy background picture. Is there a way to make this more readable? Especially in a mobile device, there were a few lists I had to skip because I just couldn’t see them. For doctored to take this more seriously, they need to see it easily as well. Thanks again for what you have done here.

    • Well said. I thought the exact same thing about the font colors over the pictures… hard to read and not professional enough for such a serious medical condition !
      Very good information!

      • I hear you Cindy. I’ve had several people mention that they would prefer the lists of symptoms without the background images. When I have a few hours to spare I’ll be sure to update this article with plain white background.

    • Hi Kara, I plan to modify this article in the near future to plain white background so that the words are easier to read. As for information about Graves’ disease, Elaine Moore has a good website: http://elaine-moore.com

  58. Seriously?!! The work this lady has put in and all you comment on spelling errors!

    • Cass Afrass says

      Spelling is important. If you want a doctor to take this seriously and appreciate all the work that did go into this, then proper spelling is imperative.

      • I completely agree. I just went through the article and made a few changes. Should you find typos or spelling errors that I’ve missed, please let me know. Good to have you at Hypothyroid Mom.

    • My thought exactly!! rude af

    • CELIA MCCOY says

      Tracy, you took the words out of my mouth. I haven’t even noticed an error because I was too caught up in the wealth of information that she’s shared. It’s because of Dana that I’m more educated on thyroid disorders/disease, this is all new to me and there was so much to learn.
      It’s obvious, the ones that are really concerned with making themselves better and less about correct wording and spelling.
      Keep up the good work Dana!!!

  59. Brigitte says

    I’m at a total shock of all the symptoms I have. My Dr hasn’t done blood work in over a year. Which last ones t4 was in the 100s. I’m 36 and pretty much have no life. I’m sitting here crying because people including my doctor has accused
    Me of illegal drug use or saying it’s all in my head. The last 2 years. I had went nile, shingles 6 times , flu 4 times can’t count infections immune system disorder yet ONLY medicine I take everyday is for depression and anxiety 1 pill .. thanks to whom ever posted this article.

    • Hi, Brigitte. I’m very sorry you’ve been so sick. Please don’t feel bad about a doctor telling you “it’s all in your head”. Many of us have been told that before. All that means is that they are not the right doctor for you. Ignore that doctor and move on. You need to move on until you find a doctor who can help you. I probably saw almost 15 doctors before I found one who actually helped me. He’s not conveniently located and he doesn’t accept insurance, so I have to deal with the drive to his office and I have to file the claim forms with my insurance company, but when I think about how I used to feel compared to how I feel today, the inconvenience is definitely worth it.

      Here is my advice to you: Read everything you can about thyroid issues. Learn about how the thyroid works, what TSH is, what T3 and T4 are, what the numbers on those tests mean, what the hormones do for your body, etc. There are websites and books where you can find that information. Educate yourself until you can have a thyroid related conversation with your doctor and you can understand everything that’s being said. I have found it very helpful to understand what my own lab reports mean and also to really understand what’s going on when I talk to my doctor. Some people prefer just to take a pill because a doctor says so without really understanding why or what that pill is supposed to do for them. That’s probably ok with some things, but because thyroid issues can be harder to get help with, I think you are better off to be more informed. Some doctors will find an educated patient to be offensive, but if that’s the case, that’s probably just not the right doctor for you. Move on and find a doctor who is not uncomfortable with your knowledge and interest in your own health.

      Look online for good thyroid doctors in your area. People write online reviews about doctors just like they do for other products and services. Read lots of reviews. Call pharmacies in your area and ask if they’ll tell you which doctors are prescribing natural desiccated thyroid medications. In my experience, doctors who are willing to prescribe those types of medicines are usually more informed about thyroid issues in general.

      Once you find a doctor you want to try, print out a list of thyroid symptoms, circle the ones you have and take it with you when you see the doctor. Type up a list of the specific issues you’ve had like shingles and attach that to the list of symptoms. Doing all that ahead of time when you have time to really think about it makes it so that you’re less likely to forget to mention something when you’re at your appointment. When a doctor wants you to have blood tests done, if they only want to do a TSH test, that is a bad sign. A good doctor will also at least look at Free T3 and Free T4. There are other thyroid related blood tests they can also do, but if they won’t at least do those two in addition to the TSH test, don’t even bother to go to the lab and get blood drawn. Just move on to the next doctor. When you call to schedule an appointment, feel free to ask what labs they run for a thyroid appointment. You may be able to eliminate a doctor that way before you even see them. Once a doctor runs blood tests, ask for a copy of the lab report. If you have to move on again and see another doctor, take that lab report with you to your next appointment in addition to the list of symptoms. If it’s recent enough, the new doctor might not make you redo the lab work.

      If you have a bad feeling about a doctor from the beginning or realize they’re not helping you after a couple of appointments, move on. If you’re still feeling badly but the doctor tell you that your lab report says you’re fine and that’s the end of the conversation, you need to move on. You need to find a doctor who doesn’t just look at the lab report, but also cares about how you’re feeling. Keep moving on until you find the right fit. When you try on shoes, you keep trying them on until you find the right fit. Do the same with your doctor. Never go back to a doctor who isn’t helping you. That’s just a waste of your time and money. You are the customer in the doctor-patient relationship. If a doctor is not providing good service, don’t keep going there and don’t feel bad about not going back. Out of all the doctors I tried, not one ever called me up to ask why I didn’t go back. You will not be hurting their feelings. Don’t look at moving on from a doctor as a bad thing. Look at it as you’re one step closer to finding the right doctor. Once you find a doctor who does actually help you to feel better, you will be very glad you put in the effort to find them, and hopefully, you will end up feeling much better.

      Keep in mind, this can be a long process. There is often a long waiting period to get an appointment with a good doctor. Don’t be afraid to make appointments at multiple places, especially if one has a three month wait and one has a six month wait. If you don’t like the doctor with the three month wait, you’ll already be half way through the six month wait when you figure that out. You can always cancel any appointments you don’t need. Just make sure to keep track of each office’s cancellation policy so you don’t end up paying a fee for canceling. Good luck to you!

    • Brigitte, This article was on my mind for many months. I knew it was necessary but I also knew it would take me so many hours to sift through the scientific literature. I’m happy that I got it together here because I hoped that it would show my Hypothyroid Mom readers that their symptoms are not all in their head. Of course not everything will be thyroid related but this article shows without a shadow of a doubt that hypothyroidism can affect every part of the body. This is your red flag to find a new thyroid doctor. Here are resources that I hope will be helpful in your search. Don’t restrict your search to doctors only in your city because it is well worth a long distance drive to a great doctor.

      https://hypothyroidmom.com/30-online-resources-to-find-a-good-thyroid-doctor/

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