Are you taking your thyroid medication properly…are you sure?

thyroid medication

After 3 years of taking thyroid medication for hypothyroidism every day, I found a great new thyroid doctor and for the first time discovered that I was taking my thyroid medication all wrong. I was taking my medication at the very same time as foods, medications, and supplements known to interfere with the absorption of thyroid medication. Yet my previous thyroid doctor and pharmacists never thought to tell me such important information.

I no longer take a T4-only levothyroxine medication like Synthroid, which is a popular prescription for hypothyroidism in mainstream medicine. I felt awful on T4 only. Some do great on these medications but I just didn’t. Our bodies are all different. I now take natural desiccated thyroid which contains both T4 and T3 thyroid hormones. My doctor has me divide my dose to twice a day to spread the affect of T3 in NDT to keep up my energy throughout the day. I take half of my dosage first thing in the morning when I wake up and the other half in the afternoon several hours apart from the food, supplements, and medications mentioned below in this article. First speak to your doctor before changing how you take your thyroid medication.

Written by Kent Holtorf, M.D.

If you are hypothyroid and taking a prescription thyroid hormone replacement drug, you may not be aware of the many rules that need to be followed when taking your medication. Something you may not know is how your other medications, vitamins, supplement, and even food choices are interfering wither thyroid medication.

If you are taking thyroid medication, hopefully your doctor or pharmacist has already shared with you the most important things to remember:

  • Take on an empty stomach first thing in the morning
  • Wait one hour before eating breakfast
  • Take it at the same time each day
  • Never miss a dose
  • Don’t take your thyroid medication at the same time as your coffee (coffee may lower the absorption of your thyroid medication)(1,2,3)

These are very important medication instructions to follow, however, there is more to the story when taking thyroid medication that you may not be aware of.

Thyroid expert Mary Shomon writes about how some thyroid patients may benefit from taking thyroid medication at night.(4) Speak to your doctor before making changes to how you take your thyroid medication.

Many medications, supplements, and foods are important to avoid or not consume within three to six hours of taking your thyroid medication. These interfere with the the body’s ability to absorb and utilize thyroid medication effectively. When an interference of absorption happens, serious things can occur. You may become under-medicated or even over-medicated depending on the substance causing the interference. So, which substances cause an absorption issue?


If you are taking thyroid medication and you are prescribed an antibiotic, you will want to make sure that you know about how thyroid drugs and antibiotics can interact, affecting the absorption of your thyroid medication.

There are a variety of reasons why you may need to take a larger-than-usual dose of thyroid hormone replacement medication— but one of the most common reasons is that you are taking a prescription or over-the-counter medication that affects absorption of your thyroid medication.

Some medications decrease the absorption of thyroid medication while others increase it.

A study from the journal Thyroid found that the antibiotic ciprofloxacin – known more commonly by brand names Cipro, Proquin, Ciproxin, Ciprobay, Cirpoxine, and Ciflox — significantly decreased the absorption of the thyroid medication.(5) [Keep in mind that some experts feel that the warning about ciprofloxacin applies also to similar quinolone antibiotics such as levofloxacin (Levaquin), lomefloxacin (Maxaquin), monifloxacin (Avelox), norfloxacin (Norox-In), and ofloxacin (Floxin).]

This means that if you are taking thyroid drugs and an antibiotic from the quinolone family, it could interfere with absorption, and cause you to become substantially more hypothyroid.

Interestingly, the antibiotic rifampin (also called rifampicin) — and known by brand names Rifadin, Rifamate and Rifater — significantly increased the absorption of the thyroid medication. This means that if you are taking the antibiotic along with your thyroid hormone replacement medication, it could actually cause you to become overmedicated, or experience hyperthyroid symptoms.

Is there a solution? Some studies have found that the impact may be minimized if the antibiotic and thyroid medications were taken at least six hours apart. But it’s not agreed upon across the board by physicians.

Your best bet is to discuss the issue with your practitioner at the time these drugs are prescribed (and before you get the prescription filled). There may be other antibiotics available for your treatment that are less likely to interfere with the effectiveness of your thyroid treatment. To be safe, take antibiotics 6 hours either before or after your thyroid medication.

Note: Remember that if you are prescribed an antibiotic, you should also take measures to help protect your digestive health.

Other Medications

While many of these other medications are needed, there are time guidelines to follow if you are also taking thyroid medication. Speak to your doctor or pharmacist if you are taking:

  • Sucralfate (Carafate), a medication often prescribed for treatment of peptic ulcer disease or gastroesophageal reflux disease decreases the absorption of thyroid medication and should be taken 8 hours before or after.
  • Cholestyramine and other cholesterol lowering drugs should be taken 4-6 hours apart from your thyroid medication.
  • Raloxifene (Evista) for osteoporosis take 12 hours apart.
  • Antidepressants: Many selective serotonin reuptake inhibitors (SSRI) like Prozac, Zoloft, and Paxil decrease the effectiveness of thyroid medication.
  • Anti-seizure: Medications such as Tegretol, Dilantin, and Phenobarbital increase the metabolism and may require your physician to increase your thyroid dose.
  • Insulin or an oral hypoglycemic drug take at least a few hours apart to avoid interaction.
  • Sevelamer – for kidney disease
  • Antiepileptic drugs – Rifampin, efavirenz, nevirapine, rifabutin and rifapentine
  • St. John’s wort
  • Imatinib (Gleevec) – cancer drug
  • Sertraline (Zoloft)

Talk to your doctor or pharmacist about all drugs and supplements that you are taking alongside your thyroid hormone replacement medication, to make sure that your timing minimizes any interference or absorption problems.


Interestingly, taking iron or calcium supplements, while helpful to your condition, can also affect the way your body absorbs your medication. This includes multivitamins and prenatal vitamins that include iron. Even reaching for an over the counter antacid like Tums or Rolaids (antacids that include calcium carbonate and/or aluminum hydroxide can significantly reduce thyroid medication absorption), needs to be taken into consideration, if you are currently taking any type of thyroid medication, observe the 4 to 6 hour rule.(6)


Similar to supplements, foods rich in iron, fiber, or calcium such as calcium fortified orange juice or yogurt should be enjoyed at least 2 hours before or after taking your thyroid.

Many times we seek different doctors for different reasons. While your endocrinologist could be prescribing your thyroid medication, the general family doctor you seek when sick with bacterial, viral, or maybe stomach issues is completely unaware of any other prescriptions. And we often times forget to mention the over the counter drugs we take, not giving the doctor the whole picture. It is always best to try and keep a list of medication, including supplements, handy to share with each doctor that you see.

Observations of these time guidelines can make a huge difference in keeping your thyroid gland and medication performing at its best.

About Dr. Kent Holtorf

Kent Holtorf, M.D. is the medical director of the Holtorf Medical Group with locations in Los Angeles, Foster City, Atlanta, and Philadelphia. He is also founder and director of the non-profit National Academy of Hypothyroidism (NAH), which is dedicated to dissemination of new information to doctors and patients on the diagnosis and treatment of hypothyroidism.

Dr. Holtorf has personally trained numerous physicians across the country in the use of bioidentical hormones, hypothyroidism, complex endocrine dysfunction, and innovative treatments of chronic fatigue syndrome, weight loss, fibromyalgia, and chronic infectious diseases, including Lyme disease.

He has been a featured guest on numerous TV shows including CNBC, ABC News, CNN, EXTRA TV, Discovery Health, The Learning Channel, The Today Show, The Doctors, Dr. Dean Edell, Glenn Beck, Nancy Grace, Fox Business, ESPN, Rush Limbaugh, CBS Sunday Morning, Sean Hannity, So Cal News, and quoted in numerous print media including the Wall Street Journal, Los Angeles Times, US New and World Report, San Francisco Chronicle, WebMD, Health, Elle, Better Homes and Garden, US Weekly, Forbes, Cosmopolitan, New York Daily News, Self magazine, among many others.


  1. Benvenga, S., et al. Altered Intestinal Absorption of L-Thyroxine Caused by Coffee. Thyroid. 2008; 18(3):293-301.
  2. Mazzaferri, E. Thyroid Hormone Therapy. Clinical Thyroidology for Patients: Summaries for Patients from Clinical Thyroidology. 2008; Vol 1, Iss 1.
  3. Sindoni, A., et al. Case Report: Coffee Impairs intestinal Absorption of Levothyroxine: Report of Additional Cases. Hot Thyroidology. Article 5/09.
  4. Bolk, N., et al. Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial. Arch Intern Med. 2010 Dec 13: 170(22):1996-2003
  5. Goldberg, A., et al. Ciprofloxacin and Rifampin Have Opposite Effects on Levothyroxine Absorption. Thyroid. October 16, 2013
  6. Dong, B. How medications affect thyroid function. West J Med. 2000 Feb; 172(2):102-6

READ NEXT: 10 Tips to Lose Weight with Hypothyroidism

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About Dana Trentini

I founded Hypothyroid Mom October 2012 in memory of the unborn baby I lost to hypothyroidism. Hypothyroid Mom is for informational purposes only and should not be considered a substitute for consulting your physician regarding medical advice pertaining to your health. Hypothyroid Mom includes affiliate links to favorite resources including the Amazon Services LLC Associates Program. Connect with me on Google+


  1. I’ll just start taking the thyroid medication is it OK if I take half in the morning and half in the evening when can I have a cup. A. Coffee help me please

  2. My numbers were only 5 when the physician put me on. I wanted Armour but they substitute any thing and everything. I am only on 15mg. Can’t seem to lose wait. I am ready to take myself off but I am taking Almstead to lose weight but that is not good for the thyroid I just realized. So after this week I want to get off to see if I can lose weight. When I went on the medication I never had any symptoms and have not noticed any different being on the meds.

  3. Thank you for this sight I think I’m the worst and was embarrassed before reading the comments I take
    My thyroid at night because I’ve been now 2 years taking it with coffee and iron pills did not know all of this info I’ve bern reading .can’t tell you how bad I’ve been feeling, seeing my doctor next week

  4. Do any supplements enhance Armor meds? Like magnesium or selenium? If so would it be helpful to take it with the Armor?

  5. I too have been taking Levothyroxide for twenty five years or more. Also on Lansoprasol and Felodopine. This is how I take mine: first the Lansoprasol, 30 minutes later Levoththyroxide. Have breakfast then take the Felodopine. Will be 80 years old next year and have never had a problem. Walk at least 3 to 4 miles a day. Not eaten meat for 30 years but have a lot of fish especially salmon. Beginning to wonder if I have the times all wrong! Maybe if I change them I could walk further! Good luck and good health to you all.

  6. Hi, I know we’re a few years further, but I was wondering if you have any scientific resources on the relationship between anti depressants and the absorption of thyroid meds? I’m pretty convinced the cymbalta I was taking lead to a lower level of thyroid meds and now I’ve stopped the cymbalta, they’re going up. I’ve scanned through the articles at the bottom but couldn’t find it in those. Thx! Your site has been so helpful

  7. I work 4 nights a week how can I find a time to take my tablets regular and on an empty stomachs use

  8. i take my leovothroxine in the morning after i drink my coffee about 45 min to 1 hour is this wrong?

  9. Is it ok to take hormone (estradiol) at the same time as synthroid, or should that be taken apart?

    • Estradiol lowers the effectiveness of thyroid medication, it’s usually best to take 1 in the morning, and the other at night.

  10. I am a Synthroid user, I also have moderate to severe redness on my face. Have been to dermatologist, no diagnosis.could this be connected to thyroid . I have a fourth of a thyroid, due to thyroidectomy. No cancer, just many cold nodules.

  11. I have been taking levothyroxine for the better part of 30 years. I am amazed that anyone taking it is not up to speed on the basics of when to take it. For at least the last 15 years, probably more, the infomation attached to the medication explains you should take it on an empty stomach, first thing in the morning. THe instruction to take it 30 mins to 1 hour before eating, and to take it at least 4 hours before taking antacids or vitamin/mineral supplements is printed on the prescription label on your pill bottle. I know there is more included on the additional material attached to the prescription bag, and since I am not on any other medications, I have not recently read the remainder of the instructions. It is imperative you read the information given to you with your prescriptions!!!

  12. You mentioned Zoloft. How does this interfere? When should each be taken?

  13. Patricia Roche says:

    I too take mine in the morning followed by my coffee 30-45 minutes later. I used to wait an hour but heard 30 minutes is okay. Not sure if there’s any problem with it.

  14. I always take the medicine in the morning but first I take the high blow pressure and then an hour later the the levotaroxine

  15. Donna Blank says:

    I had hypothyrodism for 18 years and my doctors told me to take my medication on an empty stomach and take it with water 30 minutes before breakfast or 1 hour after I eat.

  16. So i take my synthroid at 6am. Bp at 9am. Other BP at 7pm. I wait to drink decaf coffee and wait to eat usually now about 2 hrs. I still feel like crap and TSH went up to 3.50. Idk what im doing wrong but tired and sometimes feel like breathing is off

  17. I wake up at least one time a night. Therefore, at that time I take my thyroid pill. It is usually 4 hours after eating and 3 hours before I wake up. So, upon waking up, I have my coffee with no fear of causing a problem.

    • According to instructions with my levothyroxin you are to remain upright after taking the medication because if you lie down you may have issues with your esophagus.

  18. If I take my armor thyroid pill first thing in the morning, do I have to wait an hour before having coffee with cream in it?

  19. Good post, thanks for sharing this. I always try to wait at least 30 min before breakfast and never have coffee at the same time. I have heard that some people even put their alarm to take hormone at 5am… and them go sleep again to wake up at 7 and have a breakfast. Sounds a little crazy, but maybe it is not bad idea? 😉

  20. Julie Lesman says:

    I have also read, I can’t remember where, that all suplements (vitamins and minerals) should be taken at least 5 hours after thyroid meds.

  21. Rowena Rahman says:

    Great and comprehensive. Thank you so much for putting all the essentials together. A follow up question: is there a time gap that one should observe if one is taking levothyroxine and losartan H (a blood pressure med)? Thanks for your insights..

    Best Regards,

  22. Jo Ann Smallwood says:

    I’m very interested in learning more about the thyroid!

  23. So grateful for this post. I was actually taking my medication incorrectly, and neither my Doctor or my Physician mentioned the caffeine issue… which I have finally figured out was affecting my absorption of my medication. I have learned so much from this site.

    • I am taking the meds and drinking coffee. I. Started Bleeding but the doctors dont know from where.? Need more info please.

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