Functional Medicine Approach to Healing Hypothyroidism

Functional Medicine Approach to Healing Hypothyroidism

To reverse disease and support your body, you have to make important choices every day that say, “Yes, I want this! I want to feel better!  So, I’m going to love MYSELF & make a different choice today…one that supports my health.”

Written by Angela Pifer, MSN, CN

As a functional medicine practitioner, I help you see the whole picture. Symptoms are simply symptoms – a symptom of a larger issue. Let’s take a step back to figure out where these symptoms are coming from and to address the body as a whole.

I teach each of my patients the physiology of what is going on in their system. Once they understand this to the degree that they can explain it to their friends and family members, this motivates them to work on things because now, it makes sense to them. They are able to connect the dots between what is happening between their system and their symptoms. With this in mind, let’s talk about thyroid labs. I want to help arm you with the information that you will need to have an in depth conversation with your doctor about the health of your thyroid.

When testing thyroid, the lab results can be confusing. Mainstream medicine and alternative medicine do not see eye to eye with references ranges, medication or even diagnosis.

Let’s talk about thyroid function

  • The pituitary gland releases TSH thyroid stimulating hormone and it does just what the name implies – it stimulates the thyroid gland to produce a hormone called T4.
  • T4 circulates in the body and converts to hormone T3.
  • T3 is the active hormone that is absorbed by ALL the cells and tissues in the body.

Thyroid Function

When testing thyroid, doctors often look at TSH (thyroid stimulating hormone) levels first. Earlier you heard me say that the pituitary gland releases TSH “thyroid stimulating hormone.” When looking at TSH we are looking at the function of the brain and not the function of the thyroid.

Your TSH level is then referenced against a standard range.

Lab reference ranges are not that scientific

The reference ranges created for labs are not that scientific – for TSH they took a large group of people and tested TSH and created a bell curve with the results. When you are tested, your results are compared to this bell curve. This reference range is flawed because they did not delete people that had a KNOWN thyroid condition NOR people that have unknown or undiagnosed thyroid issues. The typical lab range using this bell curve will show a range for TSH of 0.5 – 4.5. If your TSH comes back at 4.2 your doctor will likely say that you are in range. But, are you? What if you have symptoms?

To correctly read a TSH range, the larger the value the more hypo-thyroid you are. The lower the value (often dipping into the negative) the more hyper-thyroid you are.

Another issue with testing TSH is that it fluctuates a lot – one study showed that it needed to retest TSH 100 times to get an average marker. This does not mean that this isn’t a useful marker. Simply make sure that this is not an isolated occurrence – if your TSH is off once, this isn’t a cue to medicate UNLESS there are very telltale symptoms present. Treat the patient and not the lab. Are their symptoms?? Dry skin, thin brittle hair, insomnia, fatigue, cold, constipation…. These are all symptoms of hypo-thyroid.

I have had personal experience with this. My routine labs returned a 7.25 TSH, which would make me very hypothyroid using both allopathic and alternative measures. My doctor was poised with the prescription pad. I had NO symptoms. While trying to convince me to medicate, the doctor even said, “Let’s medicate you – you will have so much more energy.” If you knew me personally, you would laugh at this. If I had more energy I would literally spin off the earth. I requested a second lab to confirm this. The second lab came back at 4.9 TSH.

These two labs were taken in a 48 hour period and both in the morning. If I had symptoms and my TSH was 4.9, I would have been open to the conversation to look at this further. Since I didn’t have symptoms and I am otherwise in good health, I simply test this each year and look at these markers with interest. Again, treat the patient and not the lab.

Test Markers

TSH is one marker to test. What are the other markers? Remember that TSH is released by the pituitary gland, which stimulates the thyroid to release the hormone T4. T4 converts into T3 and T3 is the active hormone that is absorbed by every cell and tissue in your sytem.

The other thyroid test markers are Total T4 and Total T3 and Free T4 and Free T3– All of these markers are hormones. Hormones are fat soluble and blood is mostly water. In order to be transported in the blood these hormones need to be bound to a protein. In order for this hormone to enter a cell, it needs to be cleaved from the protein. Once it is cleaved from a protein it is now ‘free.’

So, Total T4 and Total T3 tells us how much TOTAL bound and unbound T4 and T3 there is in the body. Total T4 is telling you how much thyroid hormone is being produced by the thyroid gland – this is important info to have. Over 90% of the hormone produced by the thyroid gland is T4.

If you have a normal Total T4 and normal Total T3, the problem isn’t that the thyroid isn’t producing hormone, it is that there is an issue cleaving the bound hormones and/or using the free hormones.

If you have high Total T4 and low Total T3, you may also want to look at another thyroid marker called RT3 or reverse T3. T4 can convert to T3 and at times of stress (whether from everyday life stress, trauma, chronic dieting, environmental toxins, ongoing low grade infections, or a side effect from certain medications) T4 converts to Reverse T3. Reverse T3 sits on the binding sites for T3 and does not allow the active T3 hormone to bind and do its job.

If you have low T4, then the thyroid is not producing enough T4. You will need to look at the specific key nutrients needed to support healthy thyroid function: like iodine, iron status, assess that you are producing enough stomach acid to convert plant based iron into the absorbable form of iron; you need adequate amounts of selenium, zinc and cofactors that we get from vitamins A, C, E and the amino acid tyrosine. You should also address your gut health. Why gut health? Because around 20% of T4 is converted into T3 in the gut. Yes, EVERYTHING is related to the gut!

Free T3 and Free T4 are arguably the more important labs to run because Free T3 is the hormone that is available to the cell to use. The majority of allopathic doctors do not run these labs. They look at TSH and Total T4 and Total T3 and that is it. Another good point to make here, is that allopathic docs don’t look past this lab because they wouldn’t change their intervention. There are synthetic thyroid medications that are widely used, across the board, with the idea that they can treat EVERYBODY. And this simply is NOT the case.

Take Home Message – please do not go out and start to over supplement with anything that I just listed out. It is important to work closely with a functional medicine practitioner to assess which pathway within the thyroid matrix needs to be addressed and then to work to bring this back into balance with a custom approach that addresses your individual needs.

I am going to leave you with one more recommendation:

Is your hypothyroidism condition an autoimmune condition?

If you have been diagnosed with a hypothyroidism condition, then you must insist on also having your thyroid antibodies tested. This is the MOST common cause of hypothyroidism in the United States. Over 90% of hypothyroidism diagnosis is due to an autoimmune condition called Hashimoto’s. Sounds like a scary word and it is not. This is simply the name of the doctor that discovered this. If your body is producing antibodies to your thyroid, this antibody tests will come back positive. The therapy for this is medication AND you’ll need to address the autoimmune condition; doing everything that you can to reduce inflammation in the body. This includes addressing gut health, removing known food sensitivities/allergies, addressing stress, getting plenty of rest, and leading an active lifestyle.

Hashimoto's thyroiditis

When you ask to have your antibodies tested, you may get some push back. A patient of mine requested an antibody test and the nurse said, “What would you change if that test came back positive?” My patient said that she didn’t know. The nurse said, “Exactly – nothing would change” so she didn’t do the test. This is simply not true. First, if you had an autoimmune condition, wouldn’t you want to know it? Wouldn’t you want to know that you need to double down on living a healthy lifestyle and that you need to address inflammation as much as possible? Wouldn’t you want to know that just because you have a diagnosis of hypothyroidism and you are given a medication, that you may not recover your symptoms because you are not addressing your autoimmune condition at the same time?

Wouldn’t you want to know that once you have an autoimmune condition, that you have an overactive immune system and you are more prone to getting a second autoimmune condition?

The patient I just mentioned, who was denied antibody testing by the nurse, was finally tested for antibodies and she did turn out to have Hashimoto’s, in fact her antibodies levels were incredibly high. Once this was identified, I put a program in place that addressed both hypothyroidism AND the autoimmune condition and she went from 232 pounds to 142 pounds within eight months. As always, knowing the bigger picture is the best approach to treating a condition.

About Angela Pifer, MSN, CN

Angela Pifer is a Functional Medicine Nutritionist and Licensed Certified Nutritionist with a Master’s in Nutrition out of Bastyr University. She is founder of the Clean & Lean Revolution.


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About Dana Trentini

Dana Trentini M.A., Ed.M., founded Hypothyroid Mom October 2012 in memory of the unborn baby she lost to hypothyroidism. This is for informational purposes only and should not be considered a substitute for consulting your physician regarding medical advice pertaining to your health. Hypothyroid Mom includes affiliate links including the Amazon Services LLC Associates Program.


  1. Been going through a LOT with thyroid. At 70 and low metabolism, at a 55-60 pulse in the am with a temp of 96.1 F – doctor thought nothing of it. Went to a doctor and got NDT, but he UNDERprescribed it and went through hell till I upped it myself. Lost 30 pounds but part of that is through calorie restriction and lots of walking. Now with swollen lymph glands in neck, am starting to see a functional medicine chiroprator – she had 15 vials of blood drawn for the various tests. She has NO CLUE about NDT but will she what she says. Cost over 600 buck for the testing – so far….
    NDT IS the way to go if you watch what is going on. See the web site “”

  2. Iv’e had hair loss for two years been to so many doctors,endocronoligist dermitiolgist several of them, finally went to a Functional doctor the only one that found I had throid problem. Hypothyroidism, My question is, should I be treated by my Funcitional doctor or the Endocrinologist?

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